Indapamide is a Medicine belongs to Thiazide diuretics and Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1409   Edition : 38,

  ►   Brandname : Natrilix,Indicontin,Inditor; CGMide; Diurix; Fanton; Ethibide; Indipam

  ►  Strength : Tablet with 1.25  mg, Tablet with 2.5  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 269   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1409   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 1.25 2.5 mg Tablet o.d. Either alone, or with other antihypertensives; a modified-release preparation may be given in a dose of 1.5 mg daily.
2 Oedema Oral 2.5 mg Tablet o.d. Increasing to 5 mg daily after 1 week if necessary.

Ref :-  Book : Martindale    Page : 1409   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : cardiac arrhythmia, Stevens-Johnson syndrome, toxic epidermal necrolysis, Pancreatitis, hepatotoxicity, systemic lupus erythematosus, hypotension, vasculitis, photosensitivity, electrolyte imbalance, hypokalaemia, metabolic alkalosis, Hyperglycaemia, hyperuricaemia, dyspepsia, headache, Blurred Vision, impotence, Restlessness,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 352   Edition : 3,

►  Drug Interaction : Drug interaction of Indapamide is with NSAIDS, Opoids, Barbiturates , Alcohol, Angiotensin converting enzyme inhibitor, Alpha blocker, Beta 2 Agonist, Corticosteroid ,  reboxetine, Amphotericin B , Carbenoxolone, Salbutamol , Corticotropin , Atracurium , Sotalol , Pimozide , Halofantrine, Terfenadine, Astemizole, digitalis,
Ref :-   Book : Martindale    Page : 1409,1406   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Indapamide -induced hypokalaemia may enhance the toxicity of digitalis glycosides and may also increase the risk of arrhythmias with drugs that prolong the QT interval, such as astemizole, terfenadine, halofantrine, pimozide, and sotalol. Indapamide may enhance the neuromuscular blocking action of competitive neuromuscular blockers, such as atracurium, probably by their hypokalaemic effect. The potassium- depleting effect of diuretics may be enhanced by corticosteroids, corticotropin, beta2 agonists such as salbutamol, carbenoxolone, amphotericin B, or reboxetine. . Indapamide may enhance the effect of other antihypertensives, particularly the first-dose hypotension that occurs with alpha blockers or ACE inhibitors. Orthostatic hypotension associated with Indapamide may be enhanced by alcohol, barbiturates, or opioids. The antihypertensive effects of Indapamide may be antagonised by drugs that cause fluid retention, such as corticosteroids, NSAIDs, or carbenoxolone; diuretics may enhance the nephrotoxicity of NSAIDs. ,
Ref :-   Book : Martindale    Page : 1409,1406   Edition : 38,


►  Contraindication : Anuria, co- administration with agents that prolong QT interval, hypersensitive to sulfonamides,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 352   Edition : 3,
  ►  Mechanism of Action :   IInhibit sodium chloride reabsorption by acting competitive antagonists at NCC sodium chloride co- transporter in apical (luminal) membrane of distal convoluted tubule cells; promote increased transcellular calcium reabsorption in distal convoluted tubule.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 352   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- ALOE VERA with Cause hypokalemia with potassium depleting diuretic .,

  ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1409   Edition : 38,


    ►    Plasma Half-life :   Min value :-   14 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1409   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA