Indinavir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 988   Edition : 38,

  ►   Brandname : Indivan,Inbec; Indease,Crixivan

  ►  Strength : Capsule with 100  mg, Capsule with 200  mg, Capsule with 333  mg, Capsule with 400  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 38, Basic & Clinical pharmacology    Page : 889   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 986   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 HIV infection and AIDS Oral 800 mg Capsule t.i.d.

Ref :-  Book : Martindale    Page : 986   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 HIV infection and AIDS 4 Year more than 4Year Oral 500 mg/m2 Capsule t.i.d.

Ref :- Book : Martindale    Page : 986   Edition : 38,
Precaution :- If a Patient is using 'Indinavir' drug in CHRONIC VIRAL HEPATITIS disease, then Please protease inhibitors hepatotoxic   if he ever suffered from HIV (Human immuodefioiency virus infection) / AIDS (Acquired immuno deficiency syndrome) disease.
►  Side Effect : Nephrolithiasis, nausea, indirect hyperbilirubinemia, headache, asthenia, blurred vision,
Ref :-   Book : Basic & Clinical pharmacology    Page : 871   Edition : 12,

►  Drug Interaction : Drug interaction of Indinavir is with Antiretroviral, , ,  Atazanavir, Rifampicin , Simvastatin , Lovastatin , Triazolam , Midazolam , Alprazolam , Pimozide , Cisapride , Methylergometrine, Ergotamine, Ergometrine , dihydroergotamine, Terfenadine, Astemizole, Flecainide Acetate , Amiodarone ,
Ref :-   Book : Martindale    Page : 987   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Indinavir is metabolised mainly by the cytochrome P450 isoenzyme CYP3A4. It may compete for the same metabolic pathways with a wide range of drugs that are metabolised similarly, often resulting in mutually increased plasma concentrations. A drug that is a significant inducer of microsomal enzymes, particularly CYP3A4, may reduce plasma concentrations of indinavir. HIV-protease inhibitors may themselves induce metabolism and may reduce plasma concentrations of other drugs. Antiarrhythmics (amiodarone and flecainide), antihistamines (astemizole and terfenadine), ergot derivatives (dihydroergotamine, ergometrine, ergotamine, and methylergometrine), gastrointestinal prokinetics (cisapride), antipsychotics (pimozide), sedatives and hypnotics (alprazolam, midazolam, and triazolam), and statins (lovastatin and simvastatin). Rifampicin and St John’s wort decrease the concentration of indinavir; use with the antiretroviral is not recommended due to the possible loss of its activity and development of resistance. Use of indinavir with atazanavir is contra-indicated as both drugs have been associated with indirect hyperbilirubinaemia. ,
Ref :-   Book : Martindale    Page : 987   Edition : 38,


►  Contraindication : hepatic impairment, hemophilia A and B,
Ref :-   Book : Martindale    Page : 973   Edition : 37, Martindale    Page : 987   Edition : 38,
  ►  Mechanism of Action :   Indinavir is an HIV-protease inhibitor with antiviral activity against HIV. ,
Ref :-   Book : Martindale    Page : 986   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- African potato with Another pathway,

  ►  Pathway with its reference as follows :-
  • anti- HIV effect . --- (Mills, E., & Cooper, C. (2005). African herbal medicines in the treatment of HIV: Hypoxis and Sutherlandia. An overview of evidence and pharmacology. Nutrition Journal, 4(19). )

  •   ►  URL -- https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-4-19,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- CINNAMON with Increased risk of hypoglycaemia, bleeding (theoretical),

      ►  Reference :-
  • Posadzki, P., Watson, L., & Ernst, E. (2012). Herb-drug interactions: an overview of systematic reviews. British Journal Of Clinical Pharmacology, no-no. http://dx.doi.org/10.1111/j.1365-2125.2012.04350.x

  •   ►  URL -- http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2125.2012.04350.x/full,

    ►   Route of Elimination :   Renal, Faecal,
    Ref :-   Book : Martindale    Page : 988   Edition : 38,


    ►    Plasma Half-life :   Min value :-   1.8 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 988   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   0.5 ,    Max value :-   1.1hours,
    Ref :-   Book : Martindale    Page : 988   Edition : 38,