Indomethacin is a Medicine belongs to Non Sterodial Anti- Inflammatory Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 74   Edition : 38,

  ►   Brandname : Idicin,Indocap,Indocid,Indolar SR,Indocid PDA

  ►  Strength : Capsule with 25  mg, Capsule with 50  mg, sustain release capsule with 75  mg, Suspension with 25/5  mg/ml, Suppository with 50  mg, Injection with   , topical gel with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 655   Edition : 12, Martindale    Page : 74   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, rectal, Topical,
Reference :-   Book : Martindale    Page : 71   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Chronic musculoskeletal disorders Oral 25 mg Capsule b.d/t.i.d Increased, if required, by 25 to 50 mg at weekly intervals to 150 to 200 mg daily.
2 Joint disorders Oral 25 mg Capsule b.d/t.i.d Increased, if required, by 25 to 50 mg at weekly intervals to 150 to 200 mg daily.,
3 Alleviate night pain and morning stiffness oral / rectal Up to 100 mg Suppository/Capsule Total daily dose.
4 Acute gout Oral 150 mg 200 mg Capsule In divided doses until all symptoms and signs subside.
5 Dysmenorrhea Oral up to 75 mg Capsule Daily.
6 Prevent miosis during cataract surgery Topical 0.1 % Eye Drop the usual dose is 2 drops, repeated after 2 hours, on the day before surgery, then 2 drops 3 hours before and 2 drops 1 hour before surgery.
7 Cystoid macular oedema Topical 0.1 % Eye Drop q.i.d. 1 drop For 15 days decreasing to 3 times daily thereafter; treatment should be continued until inflammatory signs have disappeared.
8 Other inflammatory eye disorders Topical Eye Drop t.i.d/q.i.d 1 drop of the 0.1% strength.

Ref :-  Book : Martindale    Page : 71   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Rheumatic disease 1 Month 18 Year Oral 0.5 1 mg/kg Capsule b.d.

Ref :- Book : Martindale    Page : 71   Edition : 38,
Precaution :- If a Patient is using 'Indomethacin' drug in  VON WILLEBRAND DISEASE   disease, then Please increases bleeding tendency .

Precaution :- If a Patient is using 'Indomethacin' drug in  PEPTIC ULCER DISEASE  disease, then Please do not use .

►  Side Effect : headache, vertigo, Dizziness, lightheadedness, Depression, drowsiness, tinnitus, Confusion, insomnia, gastrointestinal perforation, Psychiatric disturbances, syncope, convulsion, coma, peripheral neuropathies, Blurred Vision, oedema, corneal deposits and other ocular effects,, weight gain, hypertension, haematuria, Rashes, pruritus, Urticaria, stomatitis, alopecia, hypersensitivity reactions, leukopenia, haemolytic anaemia, purpura, thrombocytopenia, aplastic anaemia, agranulocytosis, epistaxis, Hyperglycaemia, hyperkalaemia, hypoaldosteronism, vaginal bleeding,
Ref :-   Book : Martindale    Page : 73   Edition : 38,

►  Drug Interaction : Drug interaction of Indomethacin is with , , AMINOGLYCOSIDES ,  Carbachol, Digoxin , Desmopressin , Probenecid , Diflunisal, Aspirin,
Ref :-   Book : Martindale    Page : 74   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Anti-inflammatory doses of aspirin decrease indometacin blood concentrations by about 20%. Diflunisal decreases the renal clearance and increases plasma concentrations of indometacin. Use of diflunisal with indometacin has also resulted in fatal gastrointestinal haemorrhage, and the two should not be used together. Plasma concentrations of indometacin are likely to be increased in patients receiving probenecid. Indometacin has been reported to increase plasma concentrations of aminoglycosides. Indometacin has been reported to increase the bioavailability of tiludronate. The effect of desmopressin may be enhanced by indometacin. In addition to increasing digoxin serum concentrations combination of digoxin with indometacin has been reported to reduce the half-life of the latter in premature neonates. Acetylcholine and Carbachol have been ineffective when used in patients treated with topical (ophthalmic) NSAIDs. ,
Ref :-   Book : Martindale    Page : 74   Edition : 38,


►  Contraindication : Epilepsy, parkinsonism, psychiatric disorder, Should not be given to neonates with untreated infection, with significant renal impairment, or with necrotising enterocolitis. , Infants who are bleeding (especially gastrointestinal bleeding or intracranial haemorrhage) or who have thrombocytopenia or coagulation defects ,
Ref :-   Book : Martindale    Page : 73   Edition : 38,
  ►  Mechanism of Action :   Indomethacin, is an indole derivative. It is a potent nonselective COX inhibitor and may also inhibit phospholipase A and C, reduce neutrophil migration, and decrease T-cell and B-cell proliferation.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 641   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- guggul with Another pathway,

  ►  Pathway with its reference as follows :-
  • gugguloslerones have antiinflammatory property --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CANNABIS with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- BETANIN HCL with Increase the risk of stomach bleeding, LITHIUM with Most NASDs inhibit the exretion of lithium from the body , resulting in higher blood levels of the mineral , though sulindac ., CHITOSAN with Alter the rate of absorption of water soluble drugs. , VITAMIN C with decreases plasma & leukocyte vitamin level .,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 70   Edition : 37,


    ►    Plasma Half-life :   Min value :-   2.6,    Max value :-   11.2 hours,
    Ref :-   Book : Martindale    Page : 74   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 74   Edition : 38,