Ipratropium bromide is a Medicine belongs to Antimuscarinic Anticholinergic group whose information about Brand can be referenced from   Book : Martindale    Page : 1213   Edition : 38,

  ►   Brandname : combivent,Duovent,Duoneb

  ►  Strength : Aerosol with 17  mcg/puff, Aerosol with 18  mcg/puff, Inhalant with 500  mcg/vial, Nasal Spray with 21  mcg/spray, Nasal Spray with 42  mcg/spray,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 355   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : inhalation, intranasal,
Reference :-   Book : Martindale    Page : 1212   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Reversible airways obstruction inhalation 20 micrograms Aerosol t.i.d/q.i.d
2 Reversible airways obstruction inhalation 40 micrograms Capsule t.i.d/q.i.d
3 Reversible airways obstruction inhalation 250 micrograms 500 micrograms nebulized solution q.i.d.
4 Rhinitis intranasal 42 micrograms Nasal Spray b.d/t.i.d
5 Rhinorrhoea inhalation 84 micrograms Nasal Spray q.i.d. for up to 3 weeks when rhinorrhoea is associated with seasonal allergic rhinitis

Ref :-  Book : Martindale    Page : 1238   Edition : 37, Martindale    Page : 1212   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Reversible airways obstruction under 6 Year inhalation 20 micrograms Aerosol t.i.d.
2 Reversible airways obstruction 6 Year 12 Year inhalation 20 micrograms Aerosol t.i.d.
3 Reversible airways obstruction 12 Year more than 12 Year inhalation 20 micrograms Aerosol t.i.d/q.i.d
4 Acute asthma under 6 Year inhalation 125 micrograms 250 micrograms nebulized solution
5 Acute asthma 6 Year 12 Year inhalation 250 micrograms nebulized solution
6 Rhinorrhoea 12 Year more than 12 Year inhalation 42 micrograms nebulized solution b.d/t.i.d
7 Rhinorrhoea 5 Year 11 Year inhalation 84 micrograms nebulized solution t.i.d.

Ref :- Book : Martindale    Page : 1212   Edition : 38,
►  Side Effect : dry mouth, constipation, prostatic hyperplasia, acute angle-closure glaucoma, paradoxical bronchospasm, Tachycardia, palpitations, and arrhythmias, nausea, vomiting, dyspepsia, headache, Dizziness,
Ref :-   Book : Martindale    Page : 1212   Edition : 38,

►  Drug Interaction : Drug interaction of Ipratropium bromide is with Antiseizure/Antipsychotic , Anti histamine (H1 Blocker) , Anti depressant ,  Amantadine , Phenothiazine, , , Cisapride , Domperidone , Metoclopramide ,
Ref :-   Book : Martindale    Page : 1212,1312   Edition : 38, Martindale    Page : 1344   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The effects of Ipratropium bromide and other antimuscarinics may be enhanced by use with other drugs having antimuscarinic properties, such as amantadine, some antihistamines, phenothiazine antipsychotics, and tricyclic antidepressants. Inhibition of drug-metabolising enzymes by MAOIs may possibly enhance the effects of antimuscarinics. The reduction in gastric motility caused by antimuscarinics may affect the absorption of other drugs. Antimuscarinics may also antagonise the gastrointestinal effects of cisapride, domperidone, and metoclopramide. Antimuscarinics and parasympathomimetics may counteract each others effects .,
Ref :-   Book : Martindale    Page : 1212,1312   Edition : 38,


►  Contraindication : diarrhoea, myasthenia gravis, prostatic enlargement, thyrotoxicosis, heart failure, cardiac surgery, angle -closure glucoma,
Ref :-   Book : Martindale    Page : 1212,1312   Edition : 38,
  ►  Mechanism of Action :   Antagonists at muscarinic receptors on airway smooth muscle and glands, leading to decreased bronchoconstriction and mucus secretion. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 834   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Kava kava with Another pathway, Adhatoda vasica Nees i. e. malabar nut with Another pathway, Albizzia lebbeck with Another pathway, Alstonia scholaris with Another pathway, Artemisia caerulescens with Another pathway, Belamcand chinensis with Another pathway, Benincasa hispida with Another pathway, Cissampelos sympodialis with Another pathway, Clerodendron serratum with Another pathway, Coleus forskohlii i.e. makandi with Another pathway, Elaeocarpus spharicus with Another pathway, Galphimia glauca with Another pathway, Galphimia glauca with Another pathway, Gardenia latifolia with Another pathway, Ginkgo biloba with Another pathway, Mikania glomerata with Another pathway, Lepidium sativum with Another pathway, Tulsi with Another pathway, Passiflora incarnata with Another pathway, Pavetta crassipes with Another pathway, Pichorhiza i e Kutki with Another pathway,

  ►  Pathway with its reference as follows :-
  • Kava lactones have antitissive effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Murray, A. (2013). Natural AChE Inhibitors from Plants and their Contribution to Alzheimer’s Disease Therapy. Curr Neuropharmacol, 11(4), 388–413. http://dx.doi.org/10.2174/1570159X11311040004 )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )
  • bronchodilator --- (Mali R. A review on herbal antiasthmatics. Oriental Pharmacy and Experimental Medicine. 2011;11(2):77–90. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3245822/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 1238   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA