Irinotecan is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 812   Edition : 38, Martindale    Page : 814   Edition : 38,

  ►   Brandname : Ertican, Irinotel,Irnocam,camptosar

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 814   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion,
Reference :-   Book : Martindale    Page : 812   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Refractory colorectal malignancies IV infusion 125 mg/m2 Injection Over 90 minutes once a week for 4 weeks, followed by a 2-week rest period.
2 Metastatic colorectal cancer IV infusion 180 mg/m2 Injection Over 30 to 90 minutes every 2 weeks.

Ref :-  Book : Martindale    Page : 812   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : neutropenia, diarrhea, leucopenia, anaemia, thrombocytopenia, severe hematological toxicity, nausea, vomiting, sweating, hypersalivation, abdominal cramp, lachrymation, Miosis, conjunctivitis, vasodilatation, hypotension, chill, Dizziness, hiccup, weakness, reversible alopecia, Skin reactions, Pancreatitis, Increase in liver enzyme values, bilirubin, creatinine, amylase and lypase, ,
Ref :-   Book : Martindale    Page : 813   Edition : 38,

►  Drug Interaction : Drug interaction of Irinotecan is with ,  Ketoconazole , Phenytoin , Phenobarbital , Carbamazapine ,
Ref :-   Book : Martindale    Page : 814   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Irinotecan is partly metabolised by cytochrome P450 CYP3A isoenzymes. Inducers of this system such as carbamazepine, phenobarbital, or phenytoin reduce exposure to irinotecan and its active metabolite SN-38; use with St John’s Wort is contra-indicated. Conversely, inhibitors of this system such as ketoconazole increase exposure to irinotecan and SN-38; use with ketoconazole is contra-indicated.,
Ref :-   Book : Martindale    Page : 814   Edition : 38,


►  Contraindication : Inflammatory bowel disease or bowel obstruction,
Ref :-   Book : Martindale    Page : 813   Edition : 38,
  ►  Mechanism of Action :   Irinotecan is a Inhibitors of the enzyme topoisomerase I and thus interfere with the coiling and uncoiling of DNA during replication and prevent nucleic acid synthesis.,
Ref :-   Book : Martindale    Page : 812   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vinca with Another pathway,

  ►  Pathway with its reference as follows :-
  • Vincristine arrests multiplication of cancerous cells --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- ST JOHNS WORT with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Biliary, Faecal,
    Ref :-   Book : Martindale    Page : 814   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   14 hours,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA