Isosorbide Mononitrate is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1414   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Isomin,Monicor,Angeze,Chemydur,Imdur,Ismo,Monoket,imdur-sr,Monit

  ►  Strength : Tablet with 10  mg, Tablet with 20  mg, Tablet with 30  mg, Tablet with 60  mg, Tablet with 120  mg, Capsule with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 209   Edition : 12, Martindale    Page : 1414   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1413   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Heart failure Oral 20 mg Tablet b.d/t.i.d
2 Angina pectoris Oral 20 mg Tablet b.d/t.i.d
3 Myocardial infarction Oral 20 120 mg Tablet/Capsule b.d/t.i.d

Ref :-  Book : Martindale    Page : 1413   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Dizziness, flushing of the face, tachycardia, throbbing headache, Restlessness, vomiting, Blurred Vision, hypotension, Contact dermatitis, syncope, local irritation, erythema, Localised burning sensation , ,
Ref :-   Book : Martindale    Page : 1413,1393   Edition : 38,

►  Drug Interaction : Drug interaction of Isosorbide Mononitrate is with , Alcohol,  NA

  ►    Mechanism of Drug Drug Interaction :  The hypotensive effects of Isosorbide dinitrate may be enhanced by alcohol and by vasodilators and other drugs with hypotensive actions. The effectiveness of sublingual tablet preparations may be reduced by drugs that cause dry mouth since dissolution may be delayed.,
Ref :-   Book : Martindale    Page : 1414,1394   Edition : 38,


►  Contraindication : hypotension, hypovolemia, raised intra cranial pressure, marked anaemia, angle -closure glucoma, severe renal impairment, Severe hepatic impairment, Hypothyroidism, malnutrition, or hypothermia,
Ref :-   Book : Martindale    Page : 1413,1394   Edition : 38,
  ►  Mechanism of Action :   Nitrate and nitroprusside: Donate NO, which activates guanylyl cyclase and increase dephosphorylation of myosin light chain in vascular smooth muscle, causing vasodilation .inhaled nitric oxide gas: selectively dilate the pulmonary vasculature,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 368   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal,
Ref :-   Book : Martindale    Page : 1414   Edition : 38,


►    Plasma Half-life :
  Min value :-   4 ,    Max value :-   5 hours,
Ref :-   Book : Martindale    Page : 1414   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   30 minutes,    Max value :-   1 hours,
Ref :-   Book : Martindale    Page : 1414   Edition : 38,