Isosorbide dinitrate is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1413   Edition : 38,

  ►   Brandname : Isordil,Sorbitrate,Dilatrate,Angitak; Cedocard

  ►  Strength : Tablet with 5  mg, Tablet with 10  mg, Tablet with 20  mg, Tablet with 30  mg, Tablet with 40  mg, Chewable tablets with 5  mg, Chewable tablets with 10  mg, sustained realease tablet with 40  mg, sustain release capsule with 40  mg, sublingual tablet with 2.5  mg, sublingual tablet with 5  mg, Injection with   , Spray with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 209   Edition : 12, Martindale    Page : 1413   Edition : 38, Martindale    Page : 1412   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV infusion, sublingual, Topical,
Reference :-   Book : Martindale    Page : 1412   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute angina sublingual 2.5 10 mg Tablet
2 Angina Oral 20 120 mg Tablet/Capsule Daily in divided doses.
3 Heart failure sublingual 5 10 mg Tablet Every 2 hours.
4 Heart failure Oral 60 160 mg Tablet/Capsule Daily in divided doses.
5 unstable angina IV infusion 2 mg/hour 12 mg/hour Injection Up to 20 mg/hour may be necessary in some patients.

Ref :-  Book : Martindale    Page : 1412   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Isosorbide dinitrate' drug in  aortic stenosis  disease, then Please be used with caution .

Precaution :- If a Patient is using 'Isosorbide dinitrate' drug in heart failure disease, then Please used with hydrazine instead of ace inhibitors   if he ever suffered from acute kidney injury disease.
►  Side Effect : Dizziness, flushing of the face, tachycardia, throbbing headache, vomiting, Restlessness, Blurred Vision, hypotension, syncope, , Contact dermatitis, local irritation, erythema, Localised burning sensation ,
Ref :-   Book : Martindale    Page : 1413,1393   Edition : 38,

►  Drug Interaction : Drug interaction of Isosorbide dinitrate is with , Alcohol,  NA

  ►    Mechanism of Drug Drug Interaction :  The hypotensive effects of Isosorbide dinitrate may be enhanced by alcohol and by vasodilators and other drugs with hypotensive actions. The effectiveness of sublingual tablet preparations may be reduced by drugs that cause dry mouth since dissolution may be delayed.,
Ref :-   Book : Martindale    Page : 1413,1394   Edition : 38,


►  Contraindication : hypotension, hypovolemia, raised intra cranial pressure, heart failure due to obstruction, marked anaemia, angle -closure glucoma, severe renal impairment, Severe hepatic impairment, Hypothyroidism, malnutrition, or hypothermia,
Ref :-   Book : Martindale    Page : 1413,1394   Edition : 38,
  ►  Mechanism of Action :   Nitrate and nitroprusside: Donate NO, which activates guanylyl cyclase and Increase dephosphorylation of myosin light chain in vascular smooth muscle, causing vasodilation .inhaled nitric oxide gas: selectively dilate the pulmonary vasculature,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 368   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Pineapple with Another pathway,

  ►  Pathway with its reference as follows :-
  • anti-inflamatory --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1413   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   45 min,    Max value :-   60 min (After sublingual doses),
    Ref :-   Book : Martindale    Page : 1413   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA