Isradipine is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1415   Edition : 38,

  ►   Brandname : Dynacirc,Prescal

  ►  Strength : Capsule with 2.5  mg, Capsule with 5  mg, Tablet with 5  mg, Tablet with 10  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 209   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1414   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 2.5 mg b.d. increased if necessary after 3 to 4 weeks to 5 mg twice daily.
2 hypertension Oral 1.25 mg b.d. In elderly patients.

Ref :-  Book : Martindale    Page : 1414   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension Oral 0.05 0.15 mg/kg t.i.d/q.i.d

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1645   Edition : 19,
►  Side Effect : Dizziness, flushing, headache, hypotension, peripheral edema, tachycardia, palpitations, nausea, constipation, gastrointestinal disturbance, increased micturition frequency, lethargy, eye pain, visual disturbances, syncope, vertigo, migraine, mood disturbances, Rashes, fever, abnormalities in liver function, hypersensitivity reactions, gingival hyperplasia, pruritus, myalgia, tremor, Gynaecomastia, impotence,
Ref :-   Book : Martindale    Page : 1414,1450   Edition : 38,

►  Drug Interaction : Drug interaction of Isradipine is with Cimetidine ,
Ref :-   Book : Martindale    Page : 1414   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Cimetidine increases the bioavailability of isradipine and the dose of isradipine should be reduced by 50% in patients receiving both drugs.,
Ref :-   Book : Martindale    Page : 1414   Edition : 38,


►  Contraindication : used with caution in patients with hypotension, in patients whose cardiac reserve is poor, and in those with heart failure since deterioration of heart failure,, should not be used in cardiogenic shock, should not be used to treat an anginal attack in chronic stable angina,
Ref :-   Book : Martindale    Page : 1414,1453   Edition : 38,
  ►  Mechanism of Action :   It is a peripheral and coronary vasodilator, Blockade of Ca channel by this drug resembles thas of Na channel blockade by LA. It acts on the inner side of the membrane and bind more effectively to open channels and inactivated channels, binding of the drug reduces the frequncy of opening in response to depolarization. ,
Ref :-   Book : Martindale    Page : 1487   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ginger (Zingiber officinale) with same pathway, Ginger (Zingiber officinale) with same pathway,

  ►  Pathway with its reference as follows :-
  • Ca2+ channel-blocking activity --- (Ghayur M. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. Journal of Cardiovascular Pharmacology. 2005;45(1):74-80. )
  • Ca2+ channel-blocking activity --- (Ghayur M. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. Journal of Cardiovascular Pharmacology. 2005;45(1):74-80. )
  • Ca2+ channel-blocking activity --- (Ghayur M. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. Journal of Cardiovascular Pharmacology. 2005;45(1):74-80. )
  • Ca2+ channel-blocking activity --- (Ghayur M. Ginger lowers blood pressure through blockade of voltage-dependent calcium channels. Journal of Cardiovascular Pharmacology. 2005;45(1):74-80. )

  •   ►  URL -- https://insights.ovid.com/pubmed?pmid=15613983,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- PLEURISY ROOT with It contains cardiac glycosides , it is best to avoid use of pleurisy root with heart medications such as calcium ., HOWTHORM with Intensify the blood pressure lowering effect .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf, https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Fecal, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1415   Edition : 38,


    ►    Plasma Half-life :   Min value :-   8 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1415   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1415   Edition : 38,