Itraconazole is a Medicine belongs to Antifungal group whose information about Brand can be referenced from   Book : Martindale    Page : 585   Edition : 38,

  ►   Brandname : Candistat,Canditral,Itracan,Sporanox

  ►  Strength : Capsule with 100  mg, Solution with 10  mg/ml, Injection with 10  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 858   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV infusion,
Reference :-   Book : Basic & Clinical pharmacology    Page : 858   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oesophageal candidiasis Oral 200 mg Solution Daily for 1 week.
2 Fluconazole-resistant infections Oral 100 200 mg Solution b.d. For 2 weeks.
3 Prophylaxis of susceptible fungal infections Oral 5 mg/kg Solution Daily in 2 divided doses.
4 Oropharyngeal candidiasis Oral 100 mg Capsule Daily for 15 days. or 200 mg in patients with AIDS or neutropenia,
5 Vulvovaginal candidiasis Oral 200 mg Capsule b.d. For 1 day.
6 Pityriasis versicolor Oral 200 mg Capsule Daily for 7 days.
7 Dermatophytosis Oral 100 mg Capsule Daily for 15 days.
8 Tinea cruris Oral 100 mg Capsule Daily for 7 days.
9 Tinea pedis Oral 200 mg Capsule b.d. For 7 days.
10 Nail infections Oral 200 mg Capsule Daily for 3 months or pulse therapy with 200 mg twice daily for 7 days repeated once (for fingernails) or twice (for toenails) after drug-free intervals of 21 days.
11 Systemic infections Oral 100 200 mg Capsule o.d. increased to 200 mg twice daily for invasive or disseminated infections, including cryptococcal meningitis.

Ref :-  Book : Martindale    Page : 583   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Oropharyngeal candidiasis 1 Month 12 Year Oral 3 5 mg/kg Capsule
2 Oropharyngeal candidiasis 12 Year 18 Year Oral 100 mg Capsule
3 Oropharyngeal candidiasis 12 Year 18 Year Oral up to 200 mg Capsule
4 Dermatophyte infections 1 Month 12 Year Oral 3 5 mg/kg Capsule
5 Dermatophyte infections 12 Year 18 Year Oral 200 mg Capsule
6 Onychomycosis 1 Year 12 Year Oral 5 mg/kg Capsule
7 Onychomycosis 12 Year 18 Year Oral 200 mg Capsule
8 Systemic fungal infections 1 Month 18 Year Oral 5 mg/kg Capsule o.d/b.d
9 Fungal infections 1 Month 18 Year IV 5 mg/kg Injection
10 Prophylaxis in haematological malignancy 1 Month 18 Year Oral 2.5 mg/kg Solution b.d.
11 Systemic fungal infections 1 Month 18 Year IV infusion 2.5 mg/kg Injection b.d.

Ref :- Book : Martindale    Page : 584   Edition : 38, Martindale    Page : 584   Edition : 37,
Precaution :- If a Patient is using 'Itraconazole' drug in acute kidney injury disease, then Please dose modification   if he ever suffered from Candidiosis disease.
►  Side Effect : dyspepsia, abdominal pain, nausea, vomiting, constipation, diarrhea, headache, Dizziness, allergic reaction, pruritus, Rashes, Urticaria, angioedema, photosensitivity, Stevens-Johnson syndrome, toxic epidermal necrolysis, erythema multiforme, exfoliative dermatitis, leucocytoclastic vasculitis, hepatitis, cholestatic jaundice, menstrual disturbances, blood disorder, neutropenia, leukopenia, thrombocytopenia, alopecia, oedema, hypokalaemia, peripheral neuropathy, visual disorders, tinnitus, transient or permanent hearing loss,
Ref :-   Book : Martindale    Page : 584   Edition : 38,

►  Drug Interaction : Drug interaction of Itraconazole is with Histamine H2-receptor antagonist, Proton pump inhibitor , Antacid , Antimuscarinic, Hiv Protease Inhibitors,  Ritonavir, Erythromycin , Clarithromycin , Rifampicin , Rifabutin , Phenytoin , Phenobarbital , Nevirapine, Isoniazid , Carbamazapine ,
Ref :-   Book : Martindale    Page : 585   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Enzyme-inducing drugs such as carbamazepine, isoniazid, nevirapine, phenobarbital, phenytoin, rifabutin, or rifampicin may decrease plasma concentrations of itraconazole sufficiently to reduce its effectiveness. Conversely, enzyme inhibitors such as clarithromycin, erythromycin, HIV-protease inhibitors, including ritonavir-boosted HIV-protease inhibitors, may increase plasma concentrations of itraconazole. Use of drugs that reduce stomach acidity, such as antimuscarinics, antacids, proton pump inhibitors, and histamine H2-receptor antagonists, may reduce the absorption of itraconazole. Like other triazole antifungals, itraconazole is a potent inhibitor of the cytochrome P450 isoenzyme CYP3A4, and may increase plasma concentrations of other drugs reliant upon it for their metabolism. ,
Ref :-   Book : Martindale    Page : 585   Edition : 38,


►  Contraindication : Pregnancy, in patients with a creatinine clearance of less than 30 mL/minute., should be stopped if neuropathy develops, should not be used for the treatment of less severe fungal infections such as onychomycosis in patients with evidence of, or a history of, ventricular dysfunction such as heart failure.,
Ref :-   Book : Martindale    Page : 584   Edition : 38,
  ►  Mechanism of Action :   Inhibit ultimate conversion of lanosterol to ergosterol by inhibiting 14α-sterol demethylase; the resulting decrease in ergosterol synthesis and accumulation of 14α-methyl sterols disrupt the tightly packed acyl chains of the phospholipids in the fungal membrane.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 627   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Tea tree oil with Another pathway,

  ►  Pathway with its reference as follows :-
  • Terpinen-4 have antifungal effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- COLA ACUMINATA I.E. COLA with Interact with druge by altering gastric acidity.,

      ►  Reference :-
  • Williamson, E. (2009). Stockley's Herbal Medicines Interaction .. London: Pharmacutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Biliary, Fecal, Hepatic (Metabolism), Renal, hair, stratum corneum,
    Ref :-   Book : Martindale    Page : 585   Edition : 38,


    ►    Plasma Half-life :   Min value :-   20 hours (increasing to 30 to 40 hours with continued use),    Max value :-   NA
    Ref :-   Book : Martindale    Page : 585   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   1.5 ,    Max value :-   5 hours,
    Ref :-   Book : Martindale    Page : 585   Edition : 38,