Kanamycin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 315   Edition : 38,

  ►   Brandname : Kaycin,Kantrex; Efficin; Kancin

  ►  Strength : Injection with 500  mg, Injection with 1000  mg, Injection with 75  mg, Capsule with   , nebuliser with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 828   Edition : 12, Martindale    Page : 315   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM, inhalation, IV infusion,
Reference :-   Book : Martindale    Page : 315   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute infections IM 15 mg/kg Injection To a maximum of 1.5 g daily, in 2 to 4 divided doses. The same doses may be given by intravenous infusion of a 0.25 to 0.5% solution over 30 to 60 minutes; in the UK, up to 30 mg/kg daily has been given in 2 or 3 divided doses by this route.
2 Gonococcal eye infection IM 2 gm Injection
3 Pre-operative use Oral 1 gm Capsule Every hour for 4 hours,then 1 g every 6 hours for 36 to 72 hours.
4 Hepatic encephalopathy Oral 8 12 gm Capsule Daily in divided doses.

Ref :-  Book : Martindale    Page : 315   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 DRUG-RESISTANT TUBERCULOSIS IM or IV 15 30 mg/kg Injection

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1008   Edition : 19,
Precaution :- If a Patient is using 'Kanamycin' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

►  Side Effect : local pain, inflammation, Bruising, haematoma, gastrointestinal disturbance, malabsorption syndrome,
Ref :-   Book : Martindale    Page : 315   Edition : 38,

►  Drug Interaction : Drug interaction of Kanamycin is with Bacteriostatic antibacterials, Beta-lactam antibacterial , Opiods, General anaesthetics ,  Zalcitabine, Dimenhydrinate , Furosemide , Etacrynic acid, Fludarabine, Cisplatin , Cyclosporine , Vancomycin ,
Ref :-   Book : Martindale    Page : 315,307   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Use of other nephrotoxic drugs (including other aminoglycosides, vancomycin, some cephalosporins, ciclosporin, cisplatin, and fludarabine), or of potentially ototoxic drugs such as etacrynic acid and perhaps furosemide, may increase the risk of aminoglycoside toxicity. It has been suggested that use of an antiemetic such as dimenhydrinate may mask the early symptoms of vestibular ototoxicity. The neuromuscular-blocking properties of kanamycin may be sufficient to provoke severe respiratory depression in patients given general anaesthetics or opioids. There is a theoretical possibility that the antibacterial effects of kanamycin could be reduced by bacteriostatic antibacterials, Since kanamycin have been shown to be incompatible with some beta lactams these antibacterials should be given separately if both are required; Aminoglycosides exhibit synergistic activity with a number of beta lactams. Renal excretion of zalcitabine may be reduced by kanamycin. ,
Ref :-   Book : Martindale    Page : 315,307   Edition : 38,


►  Contraindication : Oral kanamycin should be avoided in patients with gastrointestinal ulceration.,
Ref :-   Book : Martindale    Page : 315   Edition : 38,
  ►  Mechanism of Action :   Bind to 16S Rrna of the 30S ribosomal subunit and elicit concentration- dependent effects on protein synthesis. Kanamycin are bactericidal evidently due to induction of m RNA misreading ; misread m RNA causes synthesis of aberrant proteins that may activate oxidative stress pathways and/or insert in to the cell membrane, forming pores that eventually lead to cell death.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 596   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • antibiotic effect . --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 315   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   3 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 315   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 315   Edition : 38,