Ketamine is a Medicine belongs to General anaesthetics group whose information about Brand can be referenced from   Book : Martindale    Page : 1906   Edition : 38,

  ►   Brandname : Ketalar; Aneket; Keta; Ketafast; Hypnoket,Ketmin

  ►  Strength : Injection with 10  mg/ml, Injection with 50  mg/ml, Injection with 100  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 446   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion, IM, rectal, Oral, IV bolus,
Reference :-   Book : Goodman    Page : 538   Edition : 12, Martindale    Page : 1906   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Induction of anaesthesia IV 2 mg/kg Injection Over 60 second.
2 Induction of anaesthesia IM 6.5 13 mg/kg Injection An intramuscular dose of 10 mg/kg usually produces surgical anaesthesia within 3 to 4 minutes lasting for 12 to 25 minutes.
3 Induction of anaesthesia IV infusion 0.5 2 mg/kg Injection
4 For diagnostic or other procedures not involving intense pain IM 4 mg/kg Injection

Ref :-  Book : Martindale    Page : 1905   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Intubation IV 1 2 mg/kg Injection
2 Intubation IM 4 6 mg/kg Injection

Ref :- Book : Nelson's textbook of Pediatrics    Page : 321   Edition : 19,
►  Side Effect : Confusion, unpleasant dreams, hallucinations, Apnoea, , irrational behaviour, increased muscle tone, Blood pressure and heart rate may be temporarily increased, Respiration may be depressed, laryngospasm, diplopia, nystagmus, nausea, vomiting, lachrymation, hypersalivation, raised intra-ocular and CSF pressure, Transient skin rashes and pain at the site of injection,
Ref :-   Book : Martindale    Page : 1905   Edition : 38,

►  Drug Interaction : Drug interaction of Ketamine is with , Opiods, Barbiturates , ether,  Theophylline , Levothyroxine, Atracurium , Tubocurarine Chloride , Halothane ,
Ref :-   Book : Martindale    Page : 1906   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Inhalational anaesthetics, such as ether, halothane, and other cerebral depressants may prolong the effect of ketamine and delay recovery. Prolonged recovery has also occurred when barbiturates and/or opioids have been given with ketamine. It has been recommended that ketamine should not be used with ergometrine. Enhancement of the effect of tubocurarine or atracurium by ketamine, Increased cardiovascular adverse effects with levothyroxine, seizures and tachycardia attributed to an interaction between ketamine and theophylline. ,
Ref :-   Book : Martindale    Page : 1906   Edition : 38,


►  Contraindication : elevation of blood pressure, elevated CSF pressure, eye injury or increased intra-ocular pressure., Neurotic traits or psychotic disorders.,
Ref :-   Book : Martindale    Page : 1906   Edition : 38,
  ►  Mechanism of Action :   The major effect is probably produced through inhibition of the NMDA receptor complex.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 444   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Bacopa monnieri i. e brahmi with same pathway,

  ►  Pathway with its reference as follows :-
  • NMDA receptor angagonist . --- (Aguiar, Sebastian. "Neuropharmacological Review Of The Nootropic Herb Bacopa Monnieri". 16 4 (2013): 313-326. Web. 21 Jan. 2017. )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3746283/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1906   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   2 ,    Max value :-   4 hours,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 439   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA