Ketoprofen is a Medicine belongs to Non Sterodial Anti- Inflammatory Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 80   Edition : 38,

  ►   Brandname : Keral,Ketocid,Orudist; Ketofen; Infen; Ketopatch

  ►  Strength : Tablet with 12.5  mg, Capsule with 25  mg, Capsule with 50  mg, Capsule with 75  mg, Capsule with 100  mg, Capsule with 150  mg, Capsule with 200  mg, Gel with   , Suppository with   , Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 655   Edition : 12, Martindale    Page : 80   Edition : 38, Martindale    Page : 79   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical, rectal, IM,
Reference :-   Book : Martindale    Page : 79   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Rheumatic disorders rectal 100 mg Suppository At night or 100 mg twice daily.
2 Dysmenorrhea Oral 25 50 mg Tablet/Capsule t.i.d/q.i.d
3 Pain after orthopaedic surgery IM 50 100 mg Injection Every 4 hours, up to a maximum dose of 200 mg in 24 hours for up to 3 days.
4 Local relief of pain Topical 2.5 % Gel Applied 2 to 4 times daily for up to 10 days.
5 Rheumatic disorders Oral 100 200 mg Tablet/Capsule In 2 to 4 divided doses.

Ref :-  Book : Martindale    Page : 79   Edition : 38, Martindale    Page : 80   Edition : 38, Martindale    Page : 77   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : pain at the injection site, occasionally tissue damage., Topical preparations cause site reactions., suppositories may cause local irritation,
Ref :-   Book : Martindale    Page : 79   Edition : 38,

►  Drug Interaction : Drug interaction of Ketoprofen is with Probenecid ,
Ref :-   Book : Martindale    Page : 79   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Probenecid delays the excretion of ketoprofen and decreases its extent of protein binding resulting in increased plasma-ketoprofen concentrations.,
Ref :-   Book : Martindale    Page : 79   Edition : 38,


►  Contraindication : hepatic impairment, renal impairment, rectal use should be avoided in patients with a history of proctitis or haemorrhoids, severe heart failure,
Ref :-   Book : Martindale    Page : 77   Edition : 37, Martindale    Page : 79   Edition : 38,
  ►  Mechanism of Action :   Ketoprofen is a propionic acid derivative that inhibits both COX (nonselectively) and lipoxigenase.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 641   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- SENNA LEAVES with Dietary Substance is Drug Enhancer,

  ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- BETANIN HCL with Increase the risk of stomach bleeding, LITHIUM with Most NASDs inhibit the exretion of lithium from the body , resulting in higher blood levels of the mineral , though sulindac .,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 80   Edition : 38,


    ►    Plasma Half-life :   Min value :-   1.5 ,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 80   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   0.5 ,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 80   Edition : 38,