Ketotifen Fumarate is a Medicine belongs to antihistamines group whose information about Brand can be referenced from   Book : Martindale    Page : 632   Edition : 38,

  ►   Brandname : Ketasma,Zaditen,Alaway

  ►  Strength : Ophthalmic Solution with 0.025  %,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical,
Reference :-   Book : Martindale    Page : 631   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Rhinitis Oral 1 mg Twice daily with food, increased if necessary to 2 mg twice.
2 Drowsiness Oral 0.5 1 mg At night for the first few days of treatment.
3 Conjunctivitis Topical 0.025 % Eye Drop b.d.

Ref :-  Book : Martindale    Page : 631   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Rhinitis 3 Year Oral 1 mg b.d.
2 Conjunctivitis 3 Year Topical 0.025 % Eye Drop b.d.

Ref :- Book : Martindale    Page : 631   Edition : 38,
►  Side Effect : drowsiness, Dizziness, dry mouth, severe skin reactions, cystitis, hepatitis, Pain, Irritation, punctate keratitis,
Ref :-   Book : Martindale    Page : 632   Edition : 38,

►  Drug Interaction : Drug interaction of Ketotifen Fumarate is with Oral Antidiabetic Drugs,  NA

  ►    Mechanism of Drug Drug Interaction :  A reversible fall in the platelet count has been seen in a few patients receiving ketotifen with oral antidiabetics and it has been suggested that this combination should therefore be avoided. ,
Ref :-   Book : Martindale    Page : 632   Edition : 38,


►  Contraindication : Existing anti-asthma treatment should not be abruptly withdrawn after starting ketotifen therapy, should not be used for the treatment of acute asthma attacks,
Ref :-   Book : Martindale    Page : 632   Edition : 38,
  ►  Mechanism of Action :   Ketotifen is a sedating antihistamine that also has a stabilising action on mast cells analogous to that of sodium cromoglicate.,
Ref :-   Book : Martindale    Page : 631   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal, Hepatic (Metabolism),
Ref :-   Book : Martindale    Page : 632   Edition : 38,


►    Plasma Half-life :
  Min value :-   21 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 632   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   2,    Max value :-   4 hours,
Ref :-   Book : Martindale    Page : 632   Edition : 38,