L-asparaginase is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 745   Edition : 37, Martindale    Page : 746   Edition : 37,

  ►   Brandname : Elspar,Oncaspar,Leunase, Erwinase

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 746   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM, SC,
Reference :-   Book : Martindale    Page : 745   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute lymphoblastic leukaemia s.c, i.v, i.m 6000 units/m2 Injection t.i.w. Dose: (200 units/kg) given for 3 weeks.

Ref :-  Book : Martindale    Page : 745   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Acute lymphoblastic leukaemia IV 1000 units/kg Injection
2 Acute lymphoblastic leukaemia IM 6000 units/m2 Injection

Ref :- Book : Martindale    Page : 746   Edition : 37,
►  Side Effect : anaphylaxis, hypersensitivity reactions, fever, Rashes, bronchospasm, Urticaria, hypotension, laryngeal oedema, anaphylactic reactions, hypersensitivity reactions, Liver function abnormalities, alterations in blood lipids, Alterations in cholesterol, hypoalbuminaemia, Hyperammonaemia, uraemia, renal failure, Pancreatitis, Hyperglycaemia, ketoacidosis, Gastrointestinal disturbances, nausea, vomiting, CNS disturbances, drowsiness, Depression, coma, hallucinations, seizures, Parkinson- like syndrome, Parkinson- like syndrome, ,
Ref :-   Book : Martindale    Page : 745   Edition : 37,

►  Drug Interaction : Drug interaction of L-asparaginase is with Vincristine, Methotrexate,
Ref :-   Book : Martindale    Page : 745,870   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Asparaginase inhibits protein synthesis and cell replication, and therefore may interfere with the action of drugs such as methotrexate that require cell replication for their antineoplastic effect. It has been suggested that a 24-hour interval between methotrexate and a subsequent dose of asparaginase permits at least an additive therapeutic effect. If vincristine is used with asparaginase it should be given 12 to 24 hours before the enzyme: giving asparaginase with or before vincristine may reduce vincristine clearance and increase toxicity.,
Ref :-   Book : Martindale    Page : 745,870   Edition : 37,


►  Contraindication : Pregnancy, pancreatitis, hepatic impairment,
Ref :-   Book : Martindale    Page : 745   Edition : 37,
  ►  Mechanism of Action :   Asparaginase is an enzyme that acts by breaking down the amino acid L-asparagine to aspartic acid and ammonia. It interferes with the growth of those malignant cells which, unlike most healthy cells, are unable to synthesise L-asparagine for their metabolism, but resistance to its action develops fairly rapidly. Its action is reportedly specific for the G1 phase of the cell cycle.,
Ref :-   Book : Martindale    Page : 746   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA