Lacosamide is a Medicine belongs to Antiepileptics group whose information about Brand can be referenced from   Book : Martindale    Page : 528   Edition : 37,

  ►   Brandname : Vimpat

  ►  Strength : Tablet with 50  mg, Tablet with 100  mg, Tablet with 150  mg, Tablet with 200  mg, Tablet with 300  mg, Solution with 15  mg/ml, Injection with 10  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Partial seizure Oral 100 mg Tablet Increased 200 mg daily after 1 week. Further weekly increments of 100 mg may be given according to response and tolrability, to a maximum daily dose of 400 mg. The total daily dose of lacosemide should be given in 2 equally divided doses. When oral use is not feasible, lacosamide may be given by intravenous infusion over 50 to 60 minutes in the same doses as those used orally.

Ref :-  Book : Martindale    Page : 528   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Dizziness, headache, nausea, diplopia, Depression, Abnormal coordination, memory impairment, Somnolence, tremor, nystagmus, Blurred Vision, vertigo, gastrointestinal disorders, vomiting, constipation, Flatulence, pruritus, gait disturbances, asthenia, fatigue,
Ref :-   Book : Martindale    Page : 528   Edition : 37,

►  Drug Interaction : Drug interaction of Lacosamide is with Carbamazapine , Phenytoin , Phenobarbital ,
Ref :-   Book : Martindale    Page : 528   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  There are complex interaction between antiepileptics and toxicity may be inhanced without a corresponding increase in antiepileptic activity. Such interaction are very variable and unpredictable and plasma monitoring is often advisable with combination therapy. Lacosamide plasma concentration may be reduced by carbamazepine, phenytoin, and phenobarbital. Systemic exposure to lacosamide may be reduced by strong inducer of cytochrome P450 isoenzymes such as rifampicin or St johns wort. Lacosamide should be used with caution in patients also receving other drugs that prolong the PR interval, and with class I antiarrhythemic.,
Ref :-   Book : Martindale    Page : 528   Edition : 37,


►  Contraindication : second -or- third degree AV block, It should be used with caution in patients with cardiac conduction disorder or severe cardiac disease such as a history of myocardial infraction or heart failure,
Ref :-   Book : Martindale    Page : 528   Edition : 37,
  ►  Mechanism of Action :   Lacosamide enhance slow inactivation of voltage-gated Na+ channels. It also binds to the collapsin-rersponse mediator protein, CRMP-2, thereby blocking the effect of neurotrophic factors such as BDNF and NT3 on axonal and dendritic growth.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 413   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Renal, Faecal,
Ref :-   Book : Martindale    Page : 528   Edition : 37,


►    Plasma Half-life :
  Min value :-   13 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 528   Edition : 37,

►    Peak Plasma Concentration :   Min value :-   4 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 528   Edition : 37,