Lactulose is a Medicine belongs to Laxative group whose information about Brand can be referenced from   Book : Martindale    Page : 1890   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Duphalac,Livoluk,Lactugal,Lemlax,Cephulac,Cholac,Actilax, Lac-Dol, Danilax, Laevolac,Evict

  ►  Strength : Syrup with 10/50  gm/ml, Solution with   , Enema with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1112   Edition : 12, Martindale    Page : 1890   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, rectal,
Reference :-   Book : Martindale    Page : 1890   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Constipation Oral 10 20 gm Solution Dose: (15 to 30 mL) given daily in a single dose or in 2 divided doses; doses up to 45 mL daily of the solution (or up to 40 g of the reconstituted oral powder formulation) have been given.
2 Hepatic encephalopathy Oral 60 100 gm Solution Dose: (90 to 150 mL) is given daily in 3 divided doses.
3 Hepatic encephalopathy rectal 200 gm Enema Dose: (300 mL) mixed with 700 mL of water or sodium chloride 0.9% has been used as a retention enema; the enema is retained for 30 to 60 minutes, repeated every 4 to 6 hours until the patient is able to take oral medication.

Ref :-  Book : Martindale    Page : 1890   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Constipation 1 Month 1 Year Oral 2.5 mL Solution b.d.
2 Constipation 1 Year 5 Year Oral 5 mL Solution b.d.
3 Constipation 5 Year 10 Year Oral 10 mL Solution b.d.
4 Constipation 10 Year 18 Year Oral 15 mL Solution b.d.

Ref :- Book : Martindale    Page : 1890   Edition : 37,
►  Side Effect : Flatulence, cramp, nausea, vomiting, diarrhoea, hypernatraemia,
Ref :-   Book : Martindale    Page : 1890   Edition : 37,

►  Drug Interaction : Drug interaction of Lactulose is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : Galactosaemia, Intestinal obstruction,
Ref :-   Book : Martindale    Page : 1890   Edition : 37,
  ►  Mechanism of Action :   Lactulose is broken down by colonic bacteria mainly into lactic acid. This exerts a local osmotic effect in the colon resulting in increased faecal bulk and stimulation of peristalsis.,
Ref :-   Book : Martindale    Page : 1890   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Senna ripe fruit with Another pathway, Angeer with Another pathway,

  ►  Pathway with its reference as follows :-
  • relieve constipation --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Angeer having soluble fiber pectin stimulate healthy bowel movement, laxative effect . --- (Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html, http://sphinxsai.com/Vol.3No.1/pharm_jan-mar11/pdf/JM11(%20PT=03)%2008-12.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Large Intestine, Renal,
    Ref :-   Book : Martindale    Page : 1890   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA