Lamivudine is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 989   Edition : 37, Basic & Clinical pharmacology    Page : 889   Edition : 12,

  ►   Brandname : 3TC, Zeffix, Epivir, Kivexa, Ladiwin, Lamda, Lamidac, Epivir,Combivir,Trizivir

  ►  Strength : Tablet with 100  mg, Tablet with 150  mg, Tablet with 300  mg, Oral solution with 5  mg/ml, Oral solution with 10  mg/ml, with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 988   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 HIV infection Oral 300 mg Tablet Dose: Given daily as a single dose or in two divided doses.
2 Chronic hepatitis B infection Oral 100 mg Tablet o.d.

Ref :-  Book : Martindale    Page : 988   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 HIV infection Oral 4 mg/kg Solution b.d.
2 HIV infection Less than 14 kg Oral 4 mg/kg Solution b.d.
3 HIV infection 14 to 21 kg 75 mg Tablet b.d.
4 HIV infection 21 to 30 kg Oral Tablet
5 HIV infection Over 30 kg Oral 150 mg Tablet b.d.

Ref :- Book : Martindale    Page : 988   Edition : 37,
Precaution :- If a Patient is using 'Lamivudine' drug in  Gynecomastia  disease, then Please NRTI contraindicated .

►  Side Effect : abdominal pain, nausea, vomiting, diarrhoea, headache, fever, Rashes, alopecia, malaise, insomnia, Cough, arthralgia, musculoskeletal pain, Pancreatitis, anaemia, neutropenia, thrombocytopenia, Increases in liver enzymes and serum amylase, Lactic acidosis, hepatomegaly, steatosis, Immune reconstitution syndrome, central obesity, dorsocervical fat enlargement , peripheral wasting, facial wasting, breast enlargement, cushingoid appearance, hypertriglyceridaemia, hypercholesterolaemia, insulin resistance, hyperglycemia, Hyperlactataemia, abnormal behaviour, convulsion, hyperlipasaemia, hypertonia, Elevated creatine phosphokinase, myalgia, myositis, Osteonecrosis, abdominal discomfort, Pain, fatigue, respiratory-tract infections, Increases in serum lipase, and raised liver enzymes, in particular alanine aminotransferase, ,
Ref :-   Book : Martindale    Page : 987   Edition : 37,

►  Drug Interaction : Drug interaction of Lamivudine is with Zalcitabine, Zidovudine, Trimethoprim ,
Ref :-   Book : Martindale    Page : 988   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The renal excretion of lamivudine may be inhibited by other drugs mainly eliminated by active renal secretion, for example trimethoprim. Usual prophylactic doses of trimethoprim are unlikely to necessitate reductions in lamivudine dosage unless the patient has renal impairment, but the co-administration of lamivudine with the high doses of trimethoprim (as co-trimoxazole) used in pneumocystis pneumonia and toxoplasmosis should be avoided. Although there is usually no clinically significant interaction with zidovudine, severe anaemia has occasionally been reported in patients given lamivudine with zidovudine. Lamivudine may antagonize the antiviral action of zalcitabine and the two drugs should not be used together. Once daily triple nucleoside regimens of lamivudine and tenofovir with either abacavir or didanosine are associated with a high level of treatment failure and of emergence of resistance, and should be avoided,
Ref :-   Book : Martindale    Page : 988   Edition : 37,


►  Contraindication : Lactic acidosis, Progressive hepatomegaly, Lamivudine therapy should be stopped in patients who develop abdominal pain, nausea, or vomiting or with abnormal biochemical test results until pancreatitis has been excluded,
Ref :-   Book : Martindale    Page : 988   Edition : 37,
  ►  Mechanism of Action :   Lamivudine inhibits HBV DNA polymerase and HIV reverse transcriptase by competing with deoxycytidine triphosphate for incorporation into the viral DNA, resulting in chain termination.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 884   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Mulathi i.e licorice with Another pathway, Mulathi with , Mulathi with Another pathway,

  ►  Pathway with its reference as follows :-
  • Castarospermine have antiviral effect --- ( Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Castarospermine have antiviral property --- ( Pdr for herbal medicine. (2016) (4th ed., pp. 1-56363-361- 2). )
  • Triterpene saponins have Anti viral effect --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- https://books.google.co.in/books?id=KwYIsLRyDp4C&pg=SL1-PA47&dq=Kokate, +C.K.+Pharmaco, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 988   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   5 hours,    Max value :-   7 hours,
    Ref :-   Book : Martindale    Page : 988   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 988   Edition : 37,