Lamotrigine is a Medicine belongs to Antiepileptics group whose information about Brand can be referenced from   Book : Martindale    Page : 532   Edition : 37,

  ►   Brandname : Elmendos, Lamictal, Lamidus, Lamo, Lamotriax, Lamepil, Lametec

  ►  Strength : Tablet with 25  mg, Tablet with 100  mg, Tablet with 150  mg, Tablet with 200  mg, Chewable tablets with 2  mg, Chewable tablets with 5  mg, Chewable tablets with 25  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12, Basic & Clinical pharmacology    Page : 427   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 531   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Epilepsy Oral 25 mg Tablet o.d. Dose: Given as monotherapy: for 2 weeks followed by 50 mg once daily for 2 weeks; thereafter the dose is increased by a maximum of 50 to 100 mg every 1 to 2 weeks to usual maintenance doses of 100 to 200 mg daily, given as a single dose or in 2 divided doses. Some patients have required up to 500 mg daily
2 Epilepsy Oral 50 mg Tablet o.d. Dose: adjunct to therapy with enzyme-inducing antiepileptics (but not with valproate): for 2 weeks followed by 50 mg twice daily for 2 weeks; thereafter the dose is increased by a maximum of 100 mg every 1 to 2 weeks to usual maintenance doses of 200 to 400 mg daily given in 2 divided doses. Some patients have required up to 700 mg daily
3 Epilepsy Oral 25 mg Tablet Dose: In those taking valproate (and regardless of any other concomitant drugs) Given every other day for 2 weeks followed by 25 mg once daily for 2 weeks thereafter the dose is increased by a maximum of 25 to 50 mg every 1 to 2 weeks to usual maintenance doses of 100 to 200 mg daily given as a single dose or in 2 divided doses
4 Bipolar disorder Oral 200 mg Tablet Dose: Given daily daily as monotherapy; for patients taking valproate the target dose is 100 mg daily and in those taking enzyme-inducing drugs (but not with valproate) the target dose is 400 mg daily

Ref :-  Book : Martindale    Page : 531   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Absence seizure 2 Year 12 Year Oral 300 micrograms/kg Tablet
2 Epilepsy Oral 300 micrograms/kg Tablet
3 Epilepsy Oral 600 micrograms/kg Tablet
4 Epilepsy Oral 150 micrograms/kg Tablet o.d.

Ref :- Book : Martindale    Page : 531   Edition : 37,
Precaution :- If a Patient is using 'Lamotrigine' drug in  Acute Intermittent Porphyria  disease, then Please Do not use .

►  Side Effect : Stevens-Johnson syndrome, toxic epidermal necrolysis, fever, malaise, flu-like symptoms, drowsiness, lymphadenopathy, facial edema, leucopenia, neutropenia, tics, ataxia, nystagmus, tremor, thrombocytopenia, angioedema, photosensitivity, diplopia, Blurred Vision, conjunctivitis, Dizziness, insomnia, headache, Tiredness, nausea, vomiting, irritability, aggression, hallucinations, agitation, Confusion, ,
Ref :-   Book : Martindale    Page : 528   Edition : 37,

►  Drug Interaction : Drug interaction of Lamotrigine is with Valproic acid(sodium valproate), Phenobarbital , Phenytoin , Carbamazapine ,
Ref :-   Book : Martindale    Page : 530   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  There are complex interactions between antiepileptics and toxicity may be enhanced without a corresponding increase in antiepileptic activity. Such interactions are very variable and unpredictable and plasma monitoring is often advisable with combination therapy. The metabolism of lamotrigine is enhanced by the enzyme inducers carbamazepine, phenytoin, phenobarbital, and primidone, and inhibited by valproate,
Ref :-   Book : Martindale    Page : 530   Edition : 37,


►  Contraindication : renal impairment, hepatic insufficiency, Hypersensitivity,
Ref :-   Book : Martindale    Page : 529   Edition : 37,
  ►  Mechanism of Action :   Prolong inactivation of VG Na + channels acts presynaptically on VG Ca2+ channels, decreasing glutamate release,
Ref :-   Book : Basic & Clinical pharmacology    Page : 426   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Behen root with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti-Epilepsy --- (Kokate, C.K. and A.p. Purohit. Pharmacognosy. Nirali prakashan: Chennai, 2013. Print. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- VITAMIN B6 with Decrease in Nutrient Level, VITAMIN B12 with Decrease in Nutrient Level, VITAMIN D with Long -term anti-convulsant treatment appears to interfere with vitamin D activity , which might lead to softening of bones . , VITAMIN D with Long -term anticonvulsant treatment decrease blood levels of biotin ., VITAMIN E with Lower blood vitamin E levels ., CALCIUM with Long-term develop below normal blood levels of calcium , which may be related to drug -induced vitamin -D deficiency. ., VITAMIN A with Long-term lowered blood level of vitamin A .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- 5 HTP(5-HYDROXYTRYPTOPHAN) with Cause anxiety, confusion and other side effect, IODINE with Incerase side effect,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 530   Edition : 37,


    ►    Plasma Half-life :   Min value :-   24 hours,    Max value :-   35 hours,
    Ref :-   Book : Martindale    Page : 530   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   2.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 530   Edition : 37,