Lansoprazole is a Medicine belongs to Gastrointestinal drug group whose information about Brand can be referenced from   Book : Martindale    Page : 1892   Edition : 37,

  ►   Brandname :
Chexid,Lancus,Zoton,Prevacid,Agopton, Lanzor, Prevacid, Takepron


  ►  Strength :
Delayed-release capules with 15  mg, Delayed-release capules with 30  mg, Disintegrating tablets with 15  mg, Disintegrating tablets with 30  mg, Oral Suspension with 15  mg, Oral Suspension with 30  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1111   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration :
Oral, IV,
Reference :-   Book : Martindale    Page : 1891   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Dyspepsia Oral 15 30 mg o.d. Dose: for 2 to 4 weeks
2 Gastro-oesophageal reflux disease Oral 15 30 mg o.d. Dose: for 4 to 8 weeks; thereafter maintenance therapy can be continued with 15 or 30 mg once daily according to response
3 Erosive esophagitis IV infusion 30 mg Injection Dose: for 7 days over 30 minutes daily is recommended
4 Peptic ulcer Oral 30 mg o.d. Dose: Treatment is continued for 2 to 4 weeks for duodenal and 4 to 8 weeks for gastric ulcer
5 Eradication of H. pylori Oral 30 mg b.d. Dose: combined with clarithromycin 500 mg twice daily and amoxicillin 1 g twice daily or combined with clarithromycin 250 mg twice daily and metronidazole 400 mg twice daily; lansoprazole with amoxicillin and metronidazole has also been used
6 NSAIDS associated ulcer Oral 30 mg Dose: Given daily for 4 to 8 weeks.
7 Zollinger-ellison syndrome Oral 60 mg o.d. Dose: adjusted as required. Doses of up to 90 mg twice daily have been used. Daily doses greater than 120 mg should be given in divided doses

Ref :-  Book : Martindale    Page : 1891   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Erosive esophagitis 1 Year 11 Year 30 kg or less Oral 15 mg o.d.
2 Symptomatic gastro-oesophageal reflux disease 1 Year 11 Year 30 kg or less Oral 15 mg o.d.
3 Erosive esophagitis 1 Year 11 Year over 30 kg Oral 30 mg o.d.
4 Symptomatic gastro-oesophageal reflux disease 1 Year 11 Year over 30 kg Oral 30 mg o.d.
5 Erosive esophagitis 12 Year 17 Year Oral 30 mg o.d.
6 Symptomatic Non-erosive gastro-oesophageal reflux disease 12 Year 17 Year Oral 15 mg o.d.

Ref :- Book : Martindale    Page : 1892   Edition : 37,
►  Side Effect :
headache, diarrhoea, Skin rashes, pruritus, Dizziness, fatigue, constipation, nausea, vomiting, Flatulence, abdominal pain, arthralgia, myalgia, Urticaria, erythematous rashes, photosensitivity, exfoliative dermatitis, gastritis, gastrointestinal tumours, dry mouth, bullous eruptions, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis, hypersensitivity reactions, fever, bronchospasm, angioedema, anaphylaxis, pancytopenia, insomnia, Somnolence, vertigo, Reversible confusional states, agitation, Depression, hallucinations, raised liver enzymes, hepatitis, jaundice, hepatic failure, Hepatic encephalopathy, ,
Ref :-   Book : Martindale    Page : 1891,1906   Edition : 37,
►  Drug Interaction : Drug interaction of Lansoprazole is with
Antacids,  Sucralfate , Atazanavir, Voriconazole , Itraconazole , Ketoconazole , Dasatinib, Warfarin , Phenytoin , Diazepam ,
Ref :-   Book : Martindale    Page : 1891,1908,1909   Edition : 37,

  ►    Mechanism of Drug Drug Interaction : 
Lansoprazole and other proton pump inhibitors are metabolised by the cytochrome P450 system, primarily by isoenzyme CYP2C19, and to a smaller extent by CYP3A4. Inhibitors or inducers of these isoenzymes may affect exposure to lansoprazole and other proton pump inhibitors. In turn, proton pump inhibitors may alter the metabolism of some drugs metabolised by these enzymes. Lansoprazole may prolong the elimination of diazepam, phenytoin, and warfarin. Lansoprazole and other proton pump inhibitors can reduce the absorption of drugs such as dasatinib, ketoconazole, and itraconazole, whose absorption is dependent on an acid gastric pH. with voriconazole, the plasma concentration of both drugs may be increased. Other proton pump inhibitors may be similarly affected by voriconazole. Lansoprazole and other proton pump inhibitors should not be used with atazanavir, as it substantially reduces exposure to atazanavir. Antacids and sucralfate may reduce the bioavailability of lansoprazole, and should not be taken within 1 hour of a dose of lansoprazole.,
Ref :-   Book : Martindale    Page : 1891,1908,1909   Edition : 37,

►  Contraindication :
hepatic impairment,
Ref :-   Book : Martindale    Page : 1891,1907   Edition : 37,
  ►  Mechanism of Action :  
Lansoprazole is a proton pump inhibitor. It suppresses secretion of gastric acid by inhibiting the enzyme system of hydrogen/potassium adenosine triphosphatase (H+/K+ ATPase), the ‘proton pump’ of the gastric parietal cell.,
Ref :-   Book : Martindale    Page : 1891,1909   Edition : 37,

Pathway of Dietry Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions

​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :  
Hepatic (Metabolism), Renal, Faecal,
Ref :-   Book : Martindale    Page : 1891   Edition : 37,

►    Plasma Half-life :  
Min value :-   1 hours,    Max value :-   2 hours,
Ref :-   Book : Martindale    Page : 1891   Edition : 37,

►    Peak Plasma Concentration :  
Min value :-   1.5 hours,    Max value :-   2 hours,
Ref :-   Book : Martindale    Page : 1891   Edition : 37,