Letrozole is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 813   Edition : 37,

  ►   Brandname : Femara,Fempro, Oncolet, Trozet

  ►  Strength : Tablet with 2.5  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 740   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 812   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Breast cancer Oral 2.5 mg Tablet Dose: Given daily

Ref :-  Book : Martindale    Page : 813   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Precocious puberty Oral 1.25 2.5 mg/day Tablet

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1891-1892   Edition : 19,
►  Side Effect : gastrointestinal disturbance, anorexia, nausea, vomiting, diarrhoea, asthenia, hot flashes, Dizziness, drowsiness, headache, Rashes, hair thinning, vaginal dryness or bleeding, myalgia, arthralgia, bone fractures, Abnormalities in liver enzyme values, thromboembolism, increases in total cholesterol, dyspnoea, increased cough, hypertension, insomnia, Depression, peripheral oedema, osteoporosis, lymphoedema, ,
Ref :-   Book : Martindale    Page : 744,812   Edition : 37,

►  Drug Interaction : Drug interaction of Letrozole is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : premenopausal women (particularly in pregnancy),
Ref :-   Book : Martindale    Page : 744,812   Edition : 37,
  ►  Mechanism of Action :   Letrozole is a selective nonsteroidal inhibitor of aromatase, an enzyme required for estrogen synthesis,
Ref :-   Book : Basic & Clinical pharmacology    Page : 733   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Asparagus with same pathway, Celery with same pathway, Red ginger with same pathway, Onion with same pathway, Agaricus blazei with same pathway, Aesculus glabra with same pathway,

  ►  Pathway with its reference as follows :-
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )
  • Aromatase inhibitor --- (Balunas M. Natural Products as Aromatase Inhibitors. PMCID. 2008;8(6):646-682. )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3074486/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Goodman    Page : 1762   Edition : 12,


    ►    Plasma Half-life :
      Min value :-   ~41 hours,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 1762   Edition : 12,

    ►    Peak Plasma Concentration :   Min value :-   ~1 hour ,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 1762   Edition : 12,