Leuprolide is a Medicine belongs to Endocrine drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 2319   Edition : 37,

  ►   Brandname : Eligard, Lucrin, Enantone, Enantone-Gyn, Lupride, Prostap, Viadur

  ►  Strength : Injection with 5  mg/ml, Injection with 7.5  mg, Injection with 22.5  mg, Injection with 30  mg, Injection with 45  mg, Injection with 3.75  mg, Injection with 7.5  mg, Injection with 11.25  mg, Injection with 15  mg, Injection with 22.5  mg, Injection with 30  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 677   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : SC, IM,
Reference :-   Book : Martindale    Page : 2318   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Advanced prostate cancer SC 1 mg Injection Given as single daily dose
2 Endometriosis IM 3.75 mg Injection Dose: Monthly may be given as a single depot injection
3 Endometriosis SC 3.75 mg Injection Dose: Monthly may be given as a single depot injection
4 Uterine fibroids IM 3.75 mg Injection Dose: Monthly may be given as a single depot injection
5 Uterine fibroids SC 3.75 mg Injection Dose: Monthly may be given as a single depot injection

Ref :-  Book : Martindale    Page : 2318   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Precocious puberty IM 300 micrograms/kg Injection
2 Precocious puberty up to 25 kg IM 7.5 mg Injection
3 Precocious puberty 25 to 37.5 kg IM 11.25 mg Injection
4 Precocious puberty more than 37.5 kg IM 15 mg Injection
5 Precocious puberty SC 50 micrograms/kg Injection

Ref :- Book : Martindale    Page : 2319   Edition : 37,
►  Side Effect : nausea, abdominal pain, abdominal discomfort, headache, lightheadedness, increase menstrual bleeding, vaginal dryness, hot flushes, loss of libido, breast swelling, tenderness, mood changes, Nervousness, palpitations, acne, dry skin, changes in scalp and body hair, alterations in liver function tests , alterations in blood lipids, decreased glucose tolerance, arthralgia, paraesthesia, Reactions or pain may occur at the site of injection with rash (local or generalised), thrombophlebitis, swelling, pruritus, hypersensitivity reactions, bronchospasm, anaphylaxis, ,
Ref :-   Book : Martindale    Page : 2312,2313,2318   Edition : 37,

►  Drug Interaction : Drug interaction of Leuprolide is with Sex hormones, Dopamine antagonists, Phenothiazines, Corticosteroids, , ,  Digitoxin, Levodopa , Spironolactone ,
Ref :-   Book : Martindale    Page : 2313,2318   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Drugs affecting pituitary secretion of gonadotrophins may alter the response to gonadorelin or its analogues; other hormonal therapy and corticosteroids can affect the response. Spironolactone and levodopa can stimulate gonadotrophins while phenothiazines, dopamine antagonists, digoxin, and sex hormones can inhibit gonadotrophin secretion.,
Ref :-   Book : Martindale    Page : 2313,2318   Edition : 37,


►  Contraindication : in patients with pituitary adenoma as haemorrhagic infarction (pituitary apoplexy), Pregnancy,
Ref :-   Book : Martindale    Page : 2313,2318   Edition : 37,
  ►  Mechanism of Action :   Leuprolide is an analogue of gonadorelin. It stimulates the synthesis and release of follicle-stimulating hormone and, in particular, luteinising hormone in the anterior lobe of the pituitary. The secretion of endogenous gonadotrophin- releasing hormone is pulsatile and is controlled by several factors including circulating sex hormones.,
Ref :-   Book : Martindale    Page : 2313,2318   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vinca with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti cancer activity --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   3 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 2318   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA