Levetiracetam is a Medicine belongs to Antiepileptics group whose information about Brand can be referenced from   Book : Martindale    Page : 534   Edition : 37,

  ►   Brandname : Levroxa,Keppra

  ►  Strength : Tablet with 250  mg, Tablet with 500  mg, Tablet with 750  mg, Tablet with 1000  mg, Solution with 100  mg/ml, Injection with 100  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 427   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 533   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Epilepsy Oral 1 gm Tablet Dose: As an adjunct: On the first day of treatment; thereafter, the daily dose may be increased in steps of 1 g every 2 to 4 weeks until effective antiepileptic control is achieved, up to a maximum dose of 3 g daily.
2 Epilepsy Oral 500 mg Tablet Dose: For monotherapy, given daily increased after 2 weeks to 1 g daily. Further increases may be made in steps of 500 mg every 2 weeks up to a maximum of 3 g daily.

Ref :-  Book : Martindale    Page : 533   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Epilepsy 1 Month 6 Month Oral 14 mg/kg
2 Epilepsy 6 Month Less than 50 kg Oral 20 mg/kg
3 Epilepsy 50 kg or more

Ref :- Book : Martindale    Page : 533   Edition : 37,
Precaution :- If a Patient is using 'Levetiracetam' drug in  acute kidney injury   disease, then Please be used with caution .

Precaution :- If a Patient is using 'Levetiracetam' drug in Generalized, Tonic-Clonic Seizures disease, then Please Dose Modification needed   if he ever suffered from Acute Kidney Injury disease.
Precaution :- If a Patient is using 'Levetiracetam' drug in  Acute Intermittent Porphyria  disease, then Please Do not use .

►  Side Effect : amnesia, anorexia, ataxia, Depression, diarrhoea, dyspepsia, emotional lability, headache, insomnia, myalgia, nausea, Nervousness, tremor, weight gain, weight loss, abnormal behaviour, aggression, alopecia, anxiety, blood dyscrasias, Confusion, diplopia, hallucinations, hepatic failure, hepatitis, Irritability, neutropenia, Pancreatitis, pancytopenia, paraesthesia, psychotic disorder, psychotic reactions, rash, upper respiratory-tract infections, vertigo, Somnolence, weakness, Dizziness,
Ref :-   Book : Martindale    Page : 532   Edition : 37,

►  Drug Interaction : Drug interaction of Levetiracetam is with Carbamazapine ,
Ref :-   Book : Martindale    Page : 517,532   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  when levetiracetam was added to carbamazepine therapy; this interaction appeared to be due to a pharmacodynamic mechanism as blood levels of carbamazepine and its epoxide metabolite were not altered,
Ref :-   Book : Martindale    Page : 517,532   Edition : 37,


►  Contraindication : hepatic impairment, renal impairment,
Ref :-   Book : Martindale    Page : 532   Edition : 37,
  ►  Mechanism of Action :   It binds selectively to the synaptic vesicular protein SV2A and likely it modifies the synaptic release of Glutamate and GABA through an action on vesicular function.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 414   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Ballom flower with Another pathway,

  ►  Pathway with its reference as follows :-
  • Immunosuppresive effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- FOLIC ACID with Reduces blood levels of folic acid dramatically increases homocysteine levels ., VITAMIN A with Long-term lowered blood level of vitamin A ., L-CARNITINE with Long -term anticonvulsant treatment decrease blood levels of L-Carnitine . .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 532   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   7 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 532   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1.3 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 532   Edition : 37,