Levodopa is a Medicine belongs to Antiparkinsonian Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 895   Edition : 37   Martindale    Page : 895   Edition : 37  

  ►   Brandname : Levopa-C, Syndopa, Duodopa, Half Sinemet, Madopar, Sinemet, Stalevo, Tilolec, Atamet, Parcopa, Kinson, Levohexal, Isicom, Levocarb, Apo-Levocarb, Levomet
  ►  Strength : Tablet with 100 mg.  Tablet with 250 mg.  Tablet with 500 mg.  Capsule with 100 mg.  Capsule with 250 mg.  Capsule with 500 mg. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 498   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral
Reference :-   Book : Martindale    Page : 893   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Parkinson’s disease Oral 125 mg b.d. Dose: without a peripheral dopa-decarboxylase inhibitor: increased gradually every 3 to 7 days, according to response, to up to 8 g daily in divided doses.
2 Parkinson’s disease Oral Dose: With a peripheral dopa-decarboxylase inhibitor: lower doses of levodopa are used.

Ref :-  Book : Martindale    Page : 893   Edition : 37  



Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Amino acid metabolic disorders Oral 250 500 micrograms/kg q.i.d.
2 Amino acid metabolic disorders 18 Year Oral 250 500 micrograms/kg q.i.d.
3 Dystonias 3 Month Oral 250 micrograms/kg b.d/t.i.d
4 Pituitary and hypothalamic disorders Oral 500 mg

Ref :- Book : Martindale    Page : 894   Edition : 37  
Precaution :- If a Patient is using 'Levodopa' drug in  auto immune hemolytic anemia  disease, then Please Use with caution .

Precaution :- If a Patient is using 'Levodopa' drug in  auto immune hemolytic anemia  disease, then Please Use with caution .

►  Side Effect : Nausea, Vomiting, Anorexia, Orthostatic hypotension, Arrhythmia, Hypertension, Agitation, Anxiety, Euphoria, Nightmares, Insomnia, Drowsiness, Depression, Dyskinesia, Faintness, Dizziness, Involuntary movements of the face, tongue, lips, and jaw often appear first and those of the trunk and extremities later, Excessive daytime sleepiness, Sudden onset of sleep
Ref :-   Book : Martindale    Page : 889   Edition : 37.  

►  Drug Interaction : Drug interaction of Levodopa is with Drugs that modify gastric emptying.,  NA

  ►    Mechanism of Drug Drug Interaction :  The therapeutic or adverse effects of levodopa may be affected by interactions with a variety of drugs. Mechanisms may include effects on catecholamine metabolising enzymes, neurotransmitters, or receptor sites, effects on the endocrine system, and effects on gastrointestinal absorption. Drugs that modify gastric emptying may affect the absorption of levodopa
Ref :-   Book : Martindale    Page : 891   Edition : 37.  


►  Contraindication : Angle-closure glaucoma, Open angle glaucoma, Caution is also required in patients with cardiovascular disease, pulmonary disease, endocrine disorders, psychiatric disturbances, osteomalacia, hepatic or renal disease, or a history of peptic ulceration, Caution is advised when driving or operating machinery; patients who suffer such effects should not drive or operate machinery until the effects have stopped recurring
Ref :-   Book : Martindale    Page : 891   Edition : 37.  
  ►  Mechanism of Action :   Transported into the central nervous system (CNS) and converted to dopamine (which does not enter the CNS); also converted to dopamine in the periphery
Ref :-   Book : Basic & Clinical pharmacology    Page : 497   Edition : 12.  

Pathway of DIETARY Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Banana with Another pathway.   Ballom flower with Another pathway.   Fava beans i.e. bakla with same compound.  

  ►  Pathway with its reference as follows :-
  • Immunosuppresive effect --- ( )
  • Withanine is Increased Dopamine level --- (Kumar, K. (2012). Traditional and Medicinal Uses of Banana. Journal Of Pharmacognosy And Phytochemistry, 1(3). )
  • Fava beans rich in levo-dihydroxyphenylalanine(L-Dopa) the precursor of dopamine. --- (Mehran S.M., Mohseni. "Simultaneous Determination Of Levodopa And Carbidopa From Fava Bean, Green Peas And Green Beans By High Performance Liquid Gas Chromatography". JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH (2013): n. pag. Web. 10 Nov. 2016. )

  •   ►  URL --
  • http://www.phytojournal.com/vol1Issue3/Issue_sept_2012/9.1.pdf .
  • .
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708185/ .

  • DIETARY Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor.   NIACIN with Decrease in Nutrient Level.   NIACIN with Decrease in Nutrient Level.   VITAMIN C with Dietary Substance is Drug Enhancer.  

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf


    ContraIndication DIETARY Substance


    ​   ► This Medicine contraindicate with :- PROTEIN with Avoid taking drug with high protein food..  

      ►  Reference :-
  • MOHAMMAD ISMAIL, *MOHAMMAD. "DRUG-FOOD INTERACTIONS AND ROLE OF PHARMACIST". Asian Journal of Pharmaceutical and Clinical Research 2.4 (2009): n. pag. Print.

  •   ►  URL -- http://ajpcr.com/Vol2Issue4/226.pdf

    ►   Route of Elimination :   Renal, Faecal
    Ref :-   Book : Martindale    Page : 892-893   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   30 minutes,    Max value :-   60 minutes.  
    Ref :-   Book : Martindale    Page : 892   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 892   Edition : 37.