Levofloxacin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 318   Edition : 37      Page :   Edition :   

  ►   Brandname : Oftaquix, Tavanic, Glevo, Leeflox, Iquix, Levaquin, Quixin, Tavanic, Iquix, Levaquin, Fynal-OZ, L-cin, L-cin oz, levoflox
  ►  Strength : Tablet with 250 mg.  Tablet with 500 mg.  Tablet with 750 mg.  Solution with 25 mg/ml.  Injection with 5 mg/ml.  Injection with 25 mg/ml.  Ophthalmic Solution with 5 mg/ml. 

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 838   Edition : 12  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical, IV
Reference :-   Book : Basic & Clinical pharmacology    Page : 838   Edition : 12  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oral 250 500 mg Tablet o.d/b.d Usual dose for 7 to 14 days depending on the severity and nature of the infection
2 Uncomplicated urinary-tract infections Oral 250 mg Tablet o.d. Duration: For 3 days
3 Chronic bacterial prostatitis Oral 500 mg Tablet o.d. Dose: It is 28-day course of treatment
4 Complicated skin infections Oral 750 mg Dose: For 7 to 14 days
5 Hospital-acquired pneumonia Oral 750 mg Dose: For 7 to 14 days
6 Community acquired pneumonia Oral 750 mg o.d. Dose: It is a shorter course for 5 days may be given for acute bacterial sinusitis, complicated urinary-tract infections, and acute pyelonephritis.
7 Postexposure prophylaxis of inhalation anthrax Oral 500 mg Tablet o.d. It is 60-day course
8 Bacterial conjunctivitis Topical 0.5 % Eye Drop
9 IV infusion 5 mg/ml Injection Dose: susceptible infections including tuberculosis: Given over 30 to 90 minutes

Ref :-  Book : Martindale    Page : 318   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Post exposure prophylaxis of Inhalation anthrax Less than 50 kg Oral 8 mg/kg
2 Post exposure prophylaxis of Inhalation anthrax Less than 50 kg IV 8 mg/kg Injection
3 Post exposure prophylaxis of Inhalation anthrax 50 kg or more Oral 500 mg Tablet
4 Post exposure prophylaxis of Inhalation anthrax 50 kg or more IV 500 mg Injection

Ref :- Book : Martindale    Page : 318   Edition : 37  
Precaution :- If a Patient is using 'Levofloxacin' drug in  Generalized, Tonic-Clonic Seizures  disease, then Please Not to be given .

Precaution :- If a Patient is using 'Levofloxacin' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

Precaution :- If a Patient is using 'Levofloxacin' drug in  autoimmune hemolytic anemia  disease, then Please Avoid .

►  Side Effect : Gastrointestinal disturbance, Nausea, Vomiting, Diarrhea, Abdominal pain, Dyspepsia, Headache, Dizziness, Confusion, Insomnia, Restlessness, Symptomatic hyperglycaemia, Tremor, Drowsiness, Nightmares, Visual disturbances, Sensory disturbances, Hallucinations, Psychotic reactions, Depression, Convulsion, Intracranial hypertension, Paraesthesia, Peripheral neuropathy, Anaphylaxis, Myalgia, Tendon damage, Joint erosions, Crystalluria, Transient increases in serum creatinine or blood urea nitrogen, Elevated liver enzyme values, Jaundice, Hepatitis, Eosinophilia, Leukopenia, Thrombocytopenia, Tachycardia, Hypotension, Oedema, Syncope, hot flushes, Sweating, Local burning, Local discomfort, pain, Keratopathy, Corneal staining, Corneal precipitates, Corneal infiltrates, Photophobia, pruritus, Local pain, Local irritation
Ref :-   Book : Martindale    Page : 265,318   Edition : 37.  

►  Drug Interaction : Drug interaction of Levofloxacin is with , ,  Theophylline , Tizanidine , Warfarin , Glibenclamide , Methotrexate, Probenecid , Phenytoin , Quinidine , Procainamide , Amiodarone , Sotalol
Ref :-   Book : Martindale    Page : 267, 318   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Use of levofloxacin with drugs that alter blood-glucose concentrations increases the risk of blood-glucose disturbances. Levofloxacin does not appear to interact significantly with theophylline or ciclosporin. Fluoroquinolones, including levofloxacin, are known to inhibit the cytochrome P450 isoenzyme CYP1A2 and may increase plasma concentrations of drugs, such as theophylline and tizanidine, that are metabolised by this isoenzyme. Levofloxacin is reported to enhance the effect of oral anticoagulants such as warfarin and the oral antidiabetic glibenclamide. Severe hypoglycaemia, sometimes fatal, has occurred in patients also taking glibenclamide. Renal tubular secretion of methotrexate may be inhibited by levofloxacin, potentially increasing its toxicity. The excretion of levofloxacin or related drugs is reduced and plasma concentrations may be increased by probenecid. Cations such as aluminium, calcium, magnesium, or iron reduce the absorption of oral levofloxacin or related drugs when given together. Changes in the pharmacokinetics of fluoroquinolones have been reported when given with histamine H2 antagonists, possibly due to changes in gastric pH, but do not seem to be of much clinical significance. Transient increases in serum creatinine have occurred when levofloxacin is given with ciclosporin; monitoring of serum creatinine concentrations is recommended. Altered serum concentrations of phenytoin have been reported in patients also receiving levofloxacin. Some fluoroquinolones have the potential to prolong the QT interval and should be avoided in patients also receiving class Ia antiarrhythmic drugs (such as quinidine and procainamide) or class III antiarrhythmics (such as amiodarone and sotalol). In addition, caution should be exercised when they are used with other drugs known to have this effect (such as the antihistamines astemizole and terfenadine, cisapride, erythromycin, pentamidine, phenothiazines, or tricyclic antidepressants).
Ref :-   Book : Martindale    Page : 267, 318   Edition : 37.  

►  Contraindication : It should be used with caution in patients with epilepsy or a history of CNS disorders. Care is also necessary in those with renal impairment, G6PD deficiency, or myasthenia gravis. It has been suggested that this drug should not generally be used in patients aged under 18 years, pregnant women, or breast-feeding mothers., History of CNS disorder, Renal impairment, G6PD deficiency, Myasthenia gravis, Caution in patients with QT prolongation or relevant risk factors such as uncorrected electrolyte disturbances, bradycardia, or pre-existing cardiac disease
Ref :-   Book : Martindale    Page : 264,318   Edition : 37.  
  ►  Mechanism of Action :   The quinolone antibiotics target bacterial DNA gyrase and topoisomerase IV. For many gram-positive bacteria (such as S. aureus), topoisomerase IV is the primary activity inhibited by the quinolones. In contrast, DNA gyrase is the primary quinolone target in many gram-negative microbes (such as E. coli). Individual strands of double-helical DNA must be separated to permit DNA replication or transcription. However, anything that separates the strands results in "overwinding" or excessive positive supercoiling of the DNA in front of the point of separation. To combat this mechanical obstacle, the bacterial enzyme DNA gyrase is responsible for the continuous introduction of negative supercoils into DNA via an ATP-dependent reaction requiring that both strands of the DNA be cut to permit passage of a segment of DNA through the break; the break then is resealed.
Ref :-   Book : Goodman    Page : 1470-1472   Edition : 12.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor.   VITAMIN K with Decrease in Nutrient Level.   COFFEE with Dietary Substance is Drug Inhibitor.   CALCIUM with Decrease in Nutrient Level.   MAGNESIUM with Increase in Nutrient Level.  

  ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf

    ContraIndication DIETARY Substance

    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal
    Ref :-   Book : Martindale    Page : 318   Edition : 37.  

    ►    Plasma Half-life :   Min value :-   6 hours,    Max value :-   8 hours.  
    Ref :-   Book : Martindale    Page : 318   Edition : 37.  

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours.  
    Ref :-   Book : Martindale    Page : 318   Edition : 37.