Levofloxacin is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 318   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Oftaquix, Tavanic, Glevo, Leeflox, Iquix, Levaquin, Quixin,Tavanic, Iquix, Levaquin,Fynal-OZ,L-cin,L-cin oz,levoflox

  ►  Strength : Tablet with 100  mg, Tablet with 250  mg, Tablet with 500  mg, Solution with 25  mg/ml, Injection with 5  mg/ml, Injection with 25  mg/ml, Ophthalmic Solution with 5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 838   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical, IV,
Reference :-   Book : Basic & Clinical pharmacology    Page : 838   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oral 250 500 mg Tablet o.d/b.d Usual dose for 7 to 14 days depending on the severity and nature of the infection
2 Uncomplicated urinary-tract infections Oral 250 mg Tablet o.d. Dose: For 3 days
3 Chronic bacterial prostatitis Oral 500 mg Tablet o.d. Dose: It is 28-day course of treatment
4 Complicated skin infections Oral 750 mg Dose: For 7 to 14 days
5 Hospital-acquired pneumonia Oral 750 mg Dose: For 7 to 14 days
6 Community acquired pneumonia Oral 750 mg o.d. Dose: It is a shorter course for 5 days may be given for acute bacterial sinusitis, complicated urinary-tract infections, and acute pyelonephritis.
7 Postexposure prophylaxis of inhalation anthrax Oral 500 mg Tablet o.d. It is 60-day course
8 Bacterial conjunctivitis Topical 0.5 % Eye Drop
9 IV infusion 5 mg/ml Injection Dose: susceptible infections including tuberculosis: Given over 30 to 90 minutes

Ref :-  Book : Martindale    Page : 318   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Post exposure prophylaxis of Inhalation anthrax Less than 50 kg Oral 8 mg/kg
2 Post exposure prophylaxis of Inhalation anthrax Less than 50 kg IV 8 mg/kg Injection
3 Post exposure prophylaxis of Inhalation anthrax 50 kg or more Oral 500 mg Tablet
4 Post exposure prophylaxis of Inhalation anthrax 50 kg or more IV 500 mg Injection

Ref :- Book : Martindale    Page : 318   Edition : 37,
Precaution :- If a Patient is using 'Levofloxacin' drug in  Generalized, Tonic-Clonic Seizures  disease, then Please Not to be given .

Precaution :- If a Patient is using 'Levofloxacin' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution .

Precaution :- If a Patient is using 'Levofloxacin' drug in  autoimmune hemolytic anemia  disease, then Please Avoid .

►  Side Effect : gastrointestinal disturbance, nausea, vomiting, diarrhea, abdominal pain, dyspepsia, headache, Dizziness, Confusion, insomnia, Restlessness, Symptomatic hyperglycaemia, tremor, drowsiness, nightmares, visual disturbances, sensory disturbances, hallucinations, psychotic reactions, Depression, convulsion, intracranial hypertension, paraesthesia, peripheral neuropathy, anaphylaxis, myalgia, tendon damage, joint erosions, Crystalluria, transient increases in serum creatinine or blood urea nitrogen, Elevated liver enzyme values, jaundice, hepatitis, eosinophilia, leukopenia, thrombocytopenia, tachycardia, hypotension, oedema, syncope, hot flushes, sweating, local burning, Local discomfort, pain, keratopathy, corneal staining, corneal precipitates, corneal infiltrates, photophobia, pruritus, , local pain, local irritation,
Ref :-   Book : Martindale    Page : 265,318   Edition : 37,

►  Drug Interaction : Drug interaction of Levofloxacin is with Fenbufen, Enoxacin, Naproxen , Tizanidine , Clozapine , Ropinirole , Glibenclamide , Probenecid , Sildenafil , Zolmitriptan , Chlorpromazine , Abatacept , Astemizole, Fluconazole , Cisapride , Erythromycin , Pentamidine , Phenothiazine, , Cyclophosphamide , Norethisterone ,
Ref :-   Book : Martindale    Page : 264, 265, 316, 682, 773, 1531, 1956, 2027   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Use of fenbufen, enoxacin, naproxen with levofloxacin may increase the incidence of fluoroquinolone CNS adverse effects. Levofloxacin, is known to inhibit the cytochrome P450 isoenzyme CYP1A2 and may increase plasma concentrations of drugs, such as clozapine, ropinirole, tizanidine that are metabolised by this isoenzyme. Both fluconazole and levofloxacin can prolong the QT interval. The simultaneous use of i.v levofloxacin and fluconazole resulted in an episode of torsade de pointes. A reduction in zolmitriptan dosage is anticipated if it is given with levofloxacin that inhibit the cytochrome P450 isoenzyme CYP1A2. Since cyclophosphamide must undergo hepatic metabolism before it is active, interactions is possible with levofloxacin that inhibit the mixed function oxidase enzymes responsible. levofloxacin partially inhibited the metabolism of ciclosporin. ,
Ref :-   Book : Martindale    Page : 264,265,316,682,   Edition : 38,


►  Contraindication : Epilepsy, History of CNS disorder, renal impairment, G6PD deficiency, Myasthenia gravis, Caution in patients with QT prolongation or relevant risk factors such as uncorrected electrolyte disturbances, bradycardia, or pre-existing cardiac disease,
Ref :-   Book : Martindale    Page : 264,318   Edition : 37,
  ►  Mechanism of Action :   The quinolone antibiotics target bacterial DNA gyrase and topoisomerase IV. For many gram-positive bacteria (such as S. aureus), topoisomerase IV is the primary activity inhibited by the quinolones. In contrast, DNA gyrase is the primary quinolone target in many gram-negative microbes (such as E. coli). Individual strands of double-helical DNA must be separated to permit DNA replication or transcription. However, anything that separates the strands results in "overwinding" or excessive positive supercoiling of the DNA in front of the point of separation. To combat this mechanical obstacle, the bacterial enzyme DNA gyrase is responsible for the continuous introduction of negative supercoils into DNA via an ATP-dependent reaction requiring that both strands of the DNA be cut to permit passage of a segment of DNA through the break; the break then is resealed.,
Ref :-   Book : Goodman    Page : 1470-1472   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway,

  ►  Pathway with its reference as follows :-
  • Berberine is Anti-infective --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor, VITAMIN K with Decrease in Nutrient Level, COFFEE with Dietary Substance is Drug Inhibitor, CALCIUM with Decrease in Nutrient Level, MAGNESIUM with Increase in Nutrient Level,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 318   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   6 hours,    Max value :-   8 hours,
    Ref :-   Book : Martindale    Page : 318   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 318   Edition : 37,