Levosalbutamol is a Medicine belongs to Bronchodilator/Anti-asthma Drugs group whose information about Brand can be referenced from   Book :    Page :   Edition :    Martindale    Page : 1240   Edition : 37  

  ►   Brandname : Levolin Rotacap, Xopenex
  ►  Strength : Inhalation Solution with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1240   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : inhalation
Reference :-   Book : Martindale    Page : 1248   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Asthma inhalation 1 mg inhaler It is given as the hydrochloride, sulfate, or tartrate but doses are usually expressed in terms of the base; 1.15 mg of levosalbutamol hydrochloride, 2.4 mg of levosalbutamol sulfate, and 2.63 mg of levosalbutamol tartrate are equivalent to about 1 mg of levosalbutamol.
2 Acute bronchospasm inhalation 45 micrograms metered-dose aerosol 1 or 2 inhalations of the equivalent of 45 micrograms of levosalbutamol can be given from a metereddose aerosol, repeated every 4 to 6 hours as required.
3 Acute bronchospasm inhalation 630 micrograms nebuliser t.i.d. Increased if necessary to 1.25 mg three times daily.

Ref :-  Book : Martindale    Page : 1239   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Asthma 4Year
2 Asthma 6 Year 11 Year inhalation 310 630 micrograms nebuliser t.i.d.

Ref :- Book : Martindale    Page : 1240   Edition : 37  
►  Side Effect : Fine tremor of skeletal muscle (particularly the hands),, palpitations, Tachycardia, Nervous tension, Headache, Peripheral vasodilatation, Serious hypokalaemia, Myocardial ischaemia, Hypersensitivity reactions, Paradoxical bronchospasm, Angioedema, Urticaria, Hypotension, Collapse, Anxiety, Fear, Restlessness, Insomnia, Confusion, irritability, Psychotic states, Dyspnoea, Weakness, Anorexia, Nausea, Vomiting, Arrhythmia, Increase in cardiac contractility, Angina, Cardiac arrest, Dizziness, Fainting, Flushing
Ref :-   Book : Martindale    Page : 1239,1246,1544   Edition : 37.  

►  Drug Interaction : Drug interaction of Levosalbutamol is with Corticosteroids, Diuretics, , , ergot alkaloids ,  Dexamfetamine, Dopamine , Dopexamine, Ephedrine , Isometheptene, Mephentermine, Metaraminol , Methylphenidate , Phentermine, Phenylephrine , Phenylpropanolamine, Pseudoephedrine, Oxytocin , Aminophylline , Theophylline
Ref :-   Book : Martindale    Page : 1239,1247,1545   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Use of levosalbutamol and other beta2 agonists with corticosteroids, diuretics, or xanthines increases the risk of hypokalaemia, and monitoring of potassium concentrations is recommended in severe asthma, where such combination therapy is common. Increased cardiac effects may occur with drugs that increase the sensitivity of the myocardium to beta1 agonists; hazardous arrhythmias may occur with volatile anaesthetics, particularly cyclopropane or halothane. Caution is also required with thyroid hormones, and with drugs that affect cardiac conduction, such as cardiac glycosides and antiarrhythmics . Hazardous interactions resulting in severe hypertension may occur with MAOIs (including RIMAs) and sympathomimetics, especially those that have indirect actions, since MAOIs increase the amount of noradrenaline stored in adrenergic nerve endings. Sympathomimetics for which the risk is particularly high include dexamfetamine, dopamine, dopexamine, ephedrine, isometheptene, mephentermine, metaraminol, methylphenidate, phentermine, phenylephrine, phenylpropanolamine, and pseudoephedrine. Sympathomimetics with central actions may potentiate the effects of CNS stimulants, while the vasoconstrictor and pressor effects of alpha agonists may be enhanced by drugs with similar effects, such as ergot alkaloids or oxytocin. Beta2-mediated hypokalaemia may be potentiated by other drugs that cause potassium loss, including corticosteroids, potassium-depleting diuretics, and aminophylline or theophylline; patients given high doses of beta2 agonists with such drugs should have their plasma- potassium concentration monitored.
Ref :-   Book : Martindale    Page : 1239,1247,1545   Edition : 37.  

►  Contraindication : Levosalbutamol and other beta agonists should be given with caution in hyperthyroidism, myocardial insufficiency, arrhythmias, susceptibility to QT-interval prolongation, hypertension, and diabetes mellitus (especially on intravenous use—blood glucose should be monitored since ketoacidosis has been reported)., In severe asthma particular caution is also required to avoid inducing hypokalaemia as this effect may be potentiated by hypoxia or by the effect of other antiasthma drugs on potassium; plasma-potassium concentrations should be monitored., In women being treated for premature labour the risk of pulmonary oedema means that the patient’s state of hydration and cardiac and respiratory function should be monitored very carefully, Eclampsia and severe preeclampsia are also contra-indications, Other contra-indications include intra-uterine infection, intrauterine fetal death, antepartum haemorrhage (which requires immediate delivery), placenta praevia, and cord compression; beta2 agonists should not be used for threatened miscarriage.
Ref :-   Book : Martindale    Page : 1239,1247   Edition : 37.  
  ►  Mechanism of Action :   Levosalbutamol, the R(−)-enantiomer of salbutamol. Levosalbutamol is a direct-acting sympathomimetic with mainly beta-adrenergic activity and a selective action on beta2 receptors This results in its bronchodilating action being more prominent than its effect on the heart.
Ref :-   Book : Martindale    Page : 1239,1248   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Faecal, Renal
Ref :-   Book : Martindale    Page : 1247   Edition : 37.  

►    Plasma Half-life :   Min value :-   3.3 hours,    Max value :-   NA
Ref :-   Book : Martindale    Page : 1239   Edition : 37.  

►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA