Levosulpiride is a Medicine belongs to Antipsychotic group whose information about Brand can be referenced from   Book : Martindale    Page : 1136   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Arminol, Meresa, neogama Sulp, Dolmatil, Sulpitil ,Pan L,Pansec L

  ►  Strength : Tablet with   , Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1136   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM,
Reference :-   Book : Martindale    Page : 1136   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Schizophrenia Oral 200 400 mg Tablet b.d. Dose: increased if necessary up to a maximum of 1.2 g twice daily in patients with mainly positive symptoms or up to a total of 800 mg daily in patients with mainly negative symptoms.
2 Positive and negative symptoms of schizophrenia Oral 400 600 mg Tablet b.d.
3 Schizophrenia IM 200 800 mg Injection Dose: Given daily

Ref :-  Book : Martindale    Page : 1136   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Schizophrenia 14 Year Oral 200 400 mg Tablet b.d.

Ref :- Book : Martindale    Page : 1136   Edition : 37,
►  Side Effect : Sleep disturbances, overstimulation, agitation, extrapyramidal effects, dyskinesia, dry mouth, constipation, difficulty in micturition, Blurred Vision, mydriasis, tachycardia, delirium, ECG changes, hypersensitivity reactions, Urticaria, exfoliative dermatitis, erythema multiforme, contact sensitivity, photosensitivity reactions, haemolytic anaemia, aplastic anaemia, thrombocytopenic purpura, eosinophilia, fatal agranulocytosis, ,
Ref :-   Book : Martindale    Page : 1072,1135   Edition : 37,

►  Drug Interaction : Drug interaction of Levosulpiride is with Diuretics, Antimalarials, , , , Opoids, Anxiolytics, Hypnotics, General anaesthetics , Alcohol,  Cisapride ,
Ref :-   Book : Martindale    Page : 1076,1135   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Symptoms of CNS depression may be enhanced by other drugs with CNS-depressant properties including alcohol, general anaesthetics, hypnotics, anxiolytics, and opioids. When given with other drugs that produce orthostatic hypotension, dosage adjustments may be necessary. There is an increased risk of arrhythmias when antipsychotics are used with drugs that prolong the QT interval, including certain antiarrhythmics, other antipsychotics, some non-sedating antihistamines, antimalarials, and cisapride; use with diuretics that cause electrolyte imbalance (particularly hypokalaemia) may also have the same effect. There is also an increased risk of arrhythmias when tricyclic antidepressants are used with antipsychotics that prolong the QT interval. ,
Ref :-   Book : Martindale    Page : 1076,1135   Edition : 37,


►  Contraindication : pre-existing CNS depression or coma, Bone marrow suppression, phaeochromocytoma, prolactin-dependent tumours, hepatic impairment, renal impairment, Cardiovascular impairment, Cerebrovascular impairment, Respiratory function impairment, angle-closure glaucoma, History of jaundice, parkinsonism, Diabetes mellitus, Hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia, urinary retention, Sulpiride should be given with care to manic or hypomanic patients in whom it may exacerbate symptoms,
Ref :-   Book : Martindale    Page : 1075,1135   Edition : 37,
  ►  Mechanism of Action :   Sulpiride is a substituted benzamide antipsychotic that is reported to be a selective antagonist of central dopamine (D2, D3, and D4) receptors. It is also claimed to have mood elevating properties.,
Ref :-   Book : Martindale    Page : 1108   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Faecal, Renal,
Ref :-   Book : Martindale    Page : 1135   Edition : 37,


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   6 hours,
Ref :-   Book : Martindale    Page : 1135   Edition : 37,