Levosulpiride/Sulpiride is a Medicine belongs to Antipsychotic group whose information about Brand can be referenced from   Book : Martindale    Page : 1136   Edition : 37      Page :   Edition :   

  ►   Brandname : Arminol, Meresa, neogama Sulp, Dolmatil, Sulpitil , Pan L, Pansec L
  ►  Strength : Tablet with .  Injection with

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1136   Edition : 37  
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM
Reference :-   Book : Martindale    Page : 1136   Edition : 37  

Dosing of Medicine differ in Adult & Pediatrics ↓

Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Schizophrenia Oral 200 400 mg Tablet b.d. Dose: increased if necessary up to a maximum of 1.2 g twice daily in patients with mainly positive symptoms or up to a total of 800 mg daily in patients with mainly negative symptoms.
2 Positive and negative symptoms of schizophrenia Oral 400 600 mg Tablet b.d.
3 Schizophrenia IM 200 800 mg Injection Dose: Given daily

Ref :-  Book : Martindale    Page : 1136   Edition : 37  

Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Schizophrenia 14 Year Oral 200 400 mg Tablet b.d.

Ref :- Book : Martindale    Page : 1136   Edition : 37  
►  Side Effect : Sleep disturbances, Overstimulation, Agitation, Extrapyramidal effects, Dyskinesia, Dry mouth, Constipation, Difficulty in micturition, Blurred Vision, Mydriasis, Tachycardia, Delirium, ECG changes, Hypersensitivity reactions, Urticaria, Exfoliative dermatitis, Erythema multiforme, Contact sensitivity, Photosensitivity reactions, Haemolytic anaemia, Aplastic anaemia, Thrombocytopenic purpura, Eosinophilia, Fatal agranulocytosis
Ref :-   Book : Martindale    Page : 1072,1135   Edition : 37.  

►  Drug Interaction : Drug interaction of Levosulpiride/Sulpiride is with Diuretics, Antimalarials, , , ,  Cisapride , Metoclopramide
Ref :-   Book : Martindale    Page : 1076,1135   Edition : 37.  

  ►    Mechanism of Drug Drug Interaction :  Antipsychotics with dopamine-blocking activity and dopaminergic drugs such as those used to treat parkinsonism may be mutually antagonistic. Use with metoclopramide may increase the risk of antipsychotic-induced extrapyramidal effects. There is an increased risk of arrhythmias when antipsychotics are used with drugs that prolong the QT interval, including certain antiarrhythmics, other antipsychotics, some non-sedating antihistamines, antimalarials, and cisapride; use with diuretics that cause electrolyte imbalance (particularly hypokalaemia) may also have the same effect. There is also an increased risk of arrhythmias when tricyclic antidepressants are used with antipsychotics that prolong the QT interval.
Ref :-   Book : Martindale    Page : 1076,1135   Edition : 37.  

►  Contraindication : Levosulpiride and other phenothiazines are contraindicated in patients with pre-existing CNS depression or coma, bone-marrow suppression, phaeochromocytoma, or prolactin-dependent tumours. They should be used with caution or not at all in patients with impaired liver, kidney, cardiovascular, cerebrovascular, and respiratory function and in those with angle-closure glaucoma, a history of jaundice, parkinsonism, diabetes mellitus, hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia, or urinary retention, Sulpiride should be given with care to manic or hypomanic patients in whom it may exacerbate symptoms
Ref :-   Book : Martindale    Page : 1075,1135   Edition : 37.  
  ►  Mechanism of Action :   Levosulpiride/Sulpiride is a substituted benzamide antipsychotic that is reported to be a selective antagonist of central dopamine (D2, D3, and D4) receptors. It is also claimed to have mood elevating properties.
Ref :-   Book : Martindale    Page : 1136   Edition : 37.  

Pathway of DIETARY Product

​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA

DIETARY Substance Interactions

​   ► This Medicine interact with :- NA

ContraIndication DIETARY Substance

​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Faecal, Renal
Ref :-   Book : Martindale    Page : 1135   Edition : 37.  

►    Plasma Half-life :   Min value :-   NA    Max value :-   NA

►    Peak Plasma Concentration :   Min value :-   3 hours,    Max value :-   6 hours.  
Ref :-   Book : Martindale    Page : 1135   Edition : 37.