Lidocaine is a Medicine belongs to Local anaesthetics group whose information about Brand can be referenced from   Book : Martindale    Page : 2028   Edition : 37,

  ►   Brandname : Gesicain,Tivision,Xylocaine,Xylocard,Dequaspray,Laryng-O-Jet,Anestacon,Anestafoam,Dentipatch,Dilocaine,Lignospan, Nurocain, Stud 100, Gelicain, Haemo-Exhirud Bufexamac,

  ►  Strength : Injection with 0.5  %, Injection with 1  %, Injection with 1.5  %, Injection with 2  %, Injection with 4  %, Injection with   , Ointment with 2.5  %, Ointment with 5  %, Cream with 0.5  %, Cream with 4  %, Gel with 0.5  %, Gel with 2.5  %, Solution with 2  %, Solution with 2.5  %, Solution with 4  %, Patch with 23  mg/2 cm2, Patch with 46  mg/2 cm2, Suppository with   , Spray with   , Eye Drop with   , Ophthalmic gel with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 463   Edition : 12, Basic & Clinical pharmacology    Page : 463   Edition : 37, Martindale    Page : 2026   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV, IM, Topical, rectal, ophthalmic, Transdermal,
Reference :-   Book : Martindale    Page : 2026   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Local anaesthesia 500 mg Injection Dose: Given with adrenaline.
2 Local anaesthesia 200 mg Injection Dose: Given without adrenaline.
3 Sympathetic nerve block 1 % Solution Dose: doses are 50 mg (5 mL) for cervical block and 50 to 100 mg (5 to 10 mL) for lumbar block.
4 Ventricular arrhythmias IV 50 100 mg Injection Dose: Given at rate of 25 to 50 mg/minutes. If no effect is seen within 5 to 10 minutes of this loading dose, it may be repeated once or twice to a maximum dose of 200 to 300 mg in 1 hour.
5 Ventricular arrhythmias IV 1 1.5 mg/kg Injection Dose: Given at rate of 25 to 50 mg/minutes. If no effect is seen within 5 to 10 minutes of this loading dose, it may be repeated once or twice to a maximum dose of 200 to 300 mg in 1 hour.
6 Lumber epidural 1 % Solution Dose: 250 to 300 mg (25 to 30 mL) for analgesia.
7 Lumber epidural 1.5 % Solution Dose: 250 to 300 mg (15 to 20 mL) for anaesthesia.
8 Thoracic epidural 1 % Solution Dose: 200 to 300 mg (20 to 30mL).
9 Obstetric analgesia 1 % Solution Dose: 200 to 300 mg (20 to 30 mL).
10 Surgical caudal anaesthesia 1.5 % Solution Dose: 225 to 300 mh (15 to 20 mL).
11 Spinal anaesthesia 1.5 % Solution Dose: given in glucose 7.5% solution.
12 Spinal anaesthesia 5 % Solution Dose: given in glucose 7.5% solution.
13 Spinal anaesthesia 5 % Solution Dose: For labour for normal vaginal delivery: upto 50 mg(1 mL).
14 Spinal anaesthesia 1.5 % Solution Dose: For labour for normal vaginal delivery: 9 to 15 mg (0.6 to 1 mL).

Ref :-  Book : Martindale    Page : 2026   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1

Ref :- Book : Martindale    Page : 2027   Edition : 37,
►  Side Effect : Restlessness, excitement, Nervousness, paraesthesia, Dizziness, tinnitus, Blurred Vision, nausea, vomiting, muscle twitching, tremor, convulsion, Numbness of the tongue and perioral region, lightheadedness, Depression, drowsiness, respiratory failure, coma, hypotension, bradycardia, Arrhythmias, cardiac arrest, ,
Ref :-   Book : Martindale    Page : 2011,2024   Edition : 37,

►  Drug Interaction : Drug interaction of Lidocaine is with Thiazide Diuretics , Loop Diuretics , , Beta Blockers , , Antiarrhythmics, ,  Acetazolamide, Cimetidine , Propranolol , Epinephrine (adrenaline) , Ropivacaine , Bupivacaine hydrochloride ,
Ref :-   Book : Martindale    Page : 2013,2025   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  There is an increased risk of myocardial depression when amide-type local anaesthetics such as bupivacaine, levobupivacaine, lidocaine, or ropivacaine are given with antiarrhythmics. If local anaesthetics containing adrenaline are given for epidural or paracervical block during labour the use of an oxytocic drug post partum may lead to severe hypertension. The clearance of lidocaine may be reduced by propranolol and cimetidine. The cardiac depressant effects of lidocaine are additive with those of beta blockers and of other antiarrhythmics. Hypokalaemia produced by acetazolamide, loop diuretics, and thiazides antagonises the effect of lidocaine. ,
Ref :-   Book : Martindale    Page : 2013,2025   Edition : 37,


►  Contraindication : hypotensive to amide-linked local anesthetics, congenital methemoglobinemia, idiopathic methemoglobinemia,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 161   Edition : 3,
  ►  Mechanism of Action :   inhibit voltage gated sodium channels in excitable cell membrane. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 161   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Hepatic (Metabolism), Renal,
Ref :-   Book : Martindale    Page : 2025   Edition : 37,


►    Plasma Half-life :
  Min value :-   NA    Max value :-   NA


►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA