Linezolid is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 320   Edition : 37,    Page :   Edition : ,

  ►   Brandname : Linospan,Lizolid,Zyvox,Lizoforce

  ►  Strength : Tablet with 600  mg, Suspension with 100/5  mg/ml, Injection with 2  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 819   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV infusion,
Reference :-   Book : Martindale    Page : 320   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antibacterial Oral 600 mg Tablet For Gram-positive infections of the skin and respiratory tract, including those due to vancomycinresistant enterococci and meticillin-resistant Staphylococcus aureus: Given every 12 hours for 10 to 14 days; treatment for up to 28 days may be necessary if there is vancomycin resistance
2 Antibacterial IV infusion 600 mg Injection For Gram-positive infections of the skin and respiratory tract, including those due to vancomycinresistant enterococci and meticillin-resistant Staphylococcus aureus: Given (over 30 to 120 minutes) every 12 hours for 10 to 14 days; treatment for up to 28 days may be necessary if there is vancomycin resistance
3 Antibacterial Oral 400 mg Tablet For uncomplicated skin and skin structure infections: every 12 hours for 10 to 14 days is usually sufficient

Ref :-  Book : Martindale    Page : 320   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Pneumonia Oral 10 mg/kg
2 Pneumonia IV infusion 10 mg/kg Injection
3 Complicated Skin and soft tissue infections Oral 10 mg/kg
4 Complicated Skin and soft tissue infections IV infusion 10 mg/kg Injection
5 Pneumonia 7 Day 12 Year Oral 10 mg/kg
6 Pneumonia 7 Day 12 Year IV infusion 10 mg/kg Injection
7 Complicated Skin and soft tissue infections 7 Day 12 Year Oral 10 mg/kg
8 Complicated Skin and soft tissue infections 7 Day 12 Year IV infusion 10 mg/kg Injection
9 Pneumonia 12 Year 18 Year
10 Complicated skin and skin structure infections 12 Year 18 Year

Ref :- Book : Martindale    Page : 321   Edition : 37,
Precaution :- If a Patient is using 'Linezolid' drug in  PID  disease, then Please Contraindication : hypertension, thyrotoxicosis .

►  Side Effect : diarrhoea, nausea, vomiting, matallic taste, headache, insomnia, constipation, Rashes, Dizziness, convulsion, fever, oral candidiasis, vaginal candidiasis, abnormal liver fuction tests, Lactic acidosis, convulsion, peripheral or optic neuropathies, Reversible myelosuppression, anaemia, leucopenia, pancytopenia, thrombocytopenia, visual blurring, ,
Ref :-   Book : Martindale    Page : 319   Edition : 37,

►  Drug Interaction : Drug interaction of Linezolid is with Serotonin reuptake inhibitors,  Rifampicin , Dopamine , Phenylpropanolamine, Pseudoephedrine, Dextromethorphan ,
Ref :-   Book : Martindale    Page : 320   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Linezolid is a reversible, nonselective MAOI and therefore has the potential to interact with adrenergic and serotonergic drugs. Enhanced pressor activity has been reported in patients receiving linezolid with phenylpropanolamine or pseudoephedrine and initial doses of dopamine or adrenaline should be reduced. There have also been cases of serotonin syndrome when linezolid was taken with serotonin reuptake inhibitors, and similar symptoms when it was taken with dextromethorphan. The peak plasma conc. and AUC of linezolid were decreased by about 20 and 30% respectively in healthy subjects given concomitant rifampicin, possibly due to the induction of hepatic enzymes; other strong inducers of hepatic enzymes may therefore also cause decrease in linezolid exposure. ,
Ref :-   Book : Martindale    Page : 320   Edition : 37,


►  Contraindication : Bone marrow suppressant drugs, Pre-existing myelosuppression, severe renal impairment,
Ref :-   Book : Martindale    Page : 319   Edition : 37,
  ►  Mechanism of Action :   Bind to a small region of 23S rRNA of the 50S ribosomal subunit near the peptidyl transferase active center,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 598   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Inhibitor,

  ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Faecal,
    Ref :-   Book : Martindale    Page : 320   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   5 hours,    Max value :-   7 hours,
    Ref :-   Book : Martindale    Page : 320   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 320   Edition : 37,