Liothyronine Sodium (T3) is a Medicine belongs to Thyroid agent group whose information about Brand can be referenced from   Book : Martindale    Page : 2375   Edition : 37,

  ►   Brandname : Thybon, Thyrotardin N, Tertroxin, Triiodothyronine Injection, Cytomel, Triostat

  ►  Strength : Tablet with 5  mcg, Tablet with 25  mcg, Tablet with 50  mcg, Injection with 10  mcg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 695   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 2375   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hypothyroidism Oral 5 25 micrograms Tablet Dose: Given daily, increased gradually to a maintenance dose of 60 to 75 micrograms daily in 2 to 3 divided doses, although up to 100 micrograms daily may be required in some patients.
2 Hypothyroid coma Slow IV 5 20 micrograms Injection Dose: increased gradually to a maintenance dose of 60 to 75 micrograms daily in 2 to 3 divided doses, although up to 100 micrograms daily may be required in some patients.

Ref :-  Book : Martindale    Page : 2375   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Congenital hypothyroidism Oral 5 Microgram Tablet

Ref :- Book : Martindale    Page : 2375   Edition : 37,
►  Side Effect : tachycardia, palpitations, Cardiac arrhythmias, Increase in blood pressure, anginal pain, headache, Restlessness, Excitability, insomnia, tremor, muscle weakness, muscle cramps, heat intolerance, sweating, flushing, fever, weight loss, menstrual irregularities, diarrhoea, vomiting, Thyroid storm, convulsion, heart failure, death,
Ref :-   Book : Martindale    Page : 2372,2374   Edition : 37,

►  Drug Interaction : Drug interaction of Liothyronine Sodium (T3) is with , Barbiturates , ,  Oestrogen, Lovastatin , Ferrous Sulphate , Ketamine , Sucralfate , Digoxin , Propranolol , Proguanil , Chloroquine , Phenytoin , Carbamazapine , Rifampicin , Amiodarone ,
Ref :-   Book : Martindale    Page : 2372-2374   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Amiodarone may inhibit the de-iodination of thyroxine to tri-iodothyronine resulting in a decreased concentration of tri-iodothyronine with a rise in the concentration of inactive reverse tri-iodothyronine. Enzyme induction by rifampicin enhances thyroid hormone metabolism resulting in reduced serum concentrations of thyroid hormones. Thyroid hormones enhance the effects of oral. Patients on anticoagulant therapy therefore require careful monitoring. Some drugs such as lithium act directly on the thyroid gland and inhibit the release of thyroid hormones leading to clinical hypothyroidism. As thyroid status influences metabolic activity and most body systems, correction of hypothyroidism may affect other disease states and dosage of any drug treatment. In hypothyroid diabetics for instance, starting thyroid replacement therapy may increase their insulin or oral hypoglycaemic requirements. Enzyme induction by drugs such as carbamazepine, phenytoin, or barbiturates enhances thyroid hormone metabolism resulting in reduced serum concentrations of thyroid hormones. Increased thyroid-stimulating hormone concentration has been noted after the use of chloroquine with proguanil for malaria prophylaxis in a patient stabilised on levothyroxine. Studies have indicated that plasma concentrations of propranolol are reduced in hyperthyroidism compared with the euthyroid state, probably due to increased clearance. Serum-digoxin concentrations appear to be lower in hyperthyroidism and higher in hypothyroidism, which may contribute in part to the observed insensitivity of hyperthyroid patients to digoxin therapy. Sucralfate reduces absorption of levothyroxine from the gastrointestinal tract as does aluminium hydroxide, and calcium carbonate. Severe hypertension and tachycardia have been reported when ketamine was used in patients taking levothyroxine. Colestyramine significantly reduces the absorption of levothyroxine by binding with thyroid hormones in the gastrointestinal tract. Ferrous sulfate reduces absorption of levothyroxine from the gastrointestinal tract. Both decreased efficacy and increased efficacy of levothyroxine have been reported in individual patients given lovastatin. Falsely low concentrations of levothyroxine (T4) or tri-iodothyronine (T3) have been reported during treatment with some anti-inflammatory drugs. Oestrogen therapy increases serum concentrations of thyroxine-binding globulin.,
Ref :-   Book : Martindale    Page : 2372-2374   Edition : 37,


►  Contraindication : Unterated hypothyroidism, It has a narrow therapeutic index and should be used with extreme caution in patients with cardiovascular disorders including angina, heart failure, myocardial infarction, and hypertension, It should not be given to patients with adrenal insufficiency without adequate corticosteroid cover otherwise the thyroid replacement therapy might precipitate an acute adrenal crisis, Care is also required when levothyroxine is given to patients with diabetes mellitus or diabetes insipidus,
Ref :-   Book : Martindale    Page : 2372,2374   Edition : 37,
  ►  Mechanism of Action :   Activation of nuclear receptor results in gene expression with RNA formation and protein synthesis.,
Ref :-   Book : Basic & Clinical pharmacology    Page : 695   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   NA


►    Plasma Half-life :
  Min value :-   0.75 days,    Max value :-   NA
Ref :-   Book : Goodman    Page : 1143   Edition : 12,

►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours,
Ref :-   Book : Goodman    Page : 1143   Edition : 12,