Lisinopril is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1457   Edition : 37,

  ►   Brandname : Biopril,Cipril,Linoril,Carace,Zestril,Prinivil,Fibsol, Liprace, Lisinobell, Acerbon, Coric, Lisi, Lisi Lich

  ►  Strength : Tablet with 2.5  mg, Tablet with 5  mg, Tablet with 10  mg, Tablet with 20  mg, Tablet with 40  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 190   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1457   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 10 mg Tablet Dose: Given daily. Hypotension is particularly likely in patients with renovascular hypertension, volume depletion, heart failure, or severe hypertension and such patients should be given a lower initial dose of 2.5 to 5 mg once daily.
2 Heart failure Oral 2.5 mg Tablet Dose: (or 5 mg in USA) daily, increased as necessary in steps of no more than 10 mg, increased as necessary in steps of no more than 10 mg at intervals of at least 2 weeks, to a maximum maintenance dose of 35 mg (or 40 mg in the USA) daily.
3 Myocardial infarction Oral 5 mg Tablet o.d. Dose: Given for two days, then increased to 10 mg once daily. An initial dose of 2.5 mg once daily is recommended for patients with a low systolic blood pressure
4 Diabetic nephropathy Oral 10 mg Tablet o.d. Dose: For hypertensive type 2 diabetics with microalbuminuria: increased if necessary to 20 mg once daily to achieve a sitting diastolic blood pressure below 90 mmHg.

Ref :-  Book : Martindale    Page : 1457   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension 6Year Oral 70 micrograms/kg Tablet o.d.
2 hypertension 6 Year 12 Year Oral 600 micrograms/kg Tablet o.d.
3 hypertension 12 Year 18 Year Oral 2.5 mg Tablet o.d.
4 Heart failure 12 Year 18 Year Oral 2.5 mg Tablet o.d.

Ref :- Book : Martindale    Page : 1457   Edition : 37,
►  Side Effect : hypotension, Dizziness, fatigue, headache, nausea, Gastrointestinal disturbances, stroke, tachycardia, palpitations, chest pain, Increasing blood concentrations of urea and creatinine, hyperkalaemia, hyponatraemia, dry cough, Other upper respiratory tract symptoms, angioedema, bradycardia, erythema multiforme, toxic epidermal necrolysis, photosensitivity, alopecia, hypersensitivity reactions, neutropenia, agranulocytosis, stomatitis, abdominal pain, Pancreatitis, hepatocellular injury, cholestatic jaundice, muscle cramp, paraesthesia, mood disturbances, Sleep disturbances, impotence,
Ref :-   Book : Martindale    Page : 1315,1457   Edition : 37,

►  Drug Interaction : Drug interaction of Lisinopril is with , , , Potassium -Sparing Diuretics , Alcohol,  Indomethacin , Cidofovir ,
Ref :-   Book : Martindale    Page : 1318,1457   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Excessive hypotension may occur when ACE inhibitors are used with diuretics, other antihypertensives, or other agents, including alcohol, that lower blood pressure. An additive hyperkalaemic effect is possible in patients receiving ACE inhibitors with potassiumsparing diuretics, potassium supplements (including potassium-containing salt substitutes), or other drugs that can cause hyperkalaemia (such as ciclosporin or indometacin), and serum-potassium concentrations should be monitored. Potassium-sparing diuretics and potassium supplements should generally be stopped before starting ACE inhibitors in patients with heart failure.,
Ref :-   Book : Martindale    Page : 1318,1457   Edition : 37,


►  Contraindication : bilateral renal artery stenosis, history of angioedema, Pregnancy, renal failure,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 349   Edition : 3,
  ►  Mechanism of Action :   Inhibition of ACE decreases conversion of angiotensin (AT), and thereby decreases arteriolar vasoconstriction, aldosterone synthesis, renal proximal tubule Nacl reabsorption, and ADH release, also inhibit the degradation of bradykinin, and thereby increase vasodilation.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 349   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Moringa peregrina with same pathway, Achillea fragrantissima with same pathway, Rhazya stricta with same pathway,

  ►  Pathway with its reference as follows :-
  • Moringa peregrina act as ACE inhibitor. --- (Fahad, M. (2017). Journal Of Medicinal Plants Research., 10(8), 93-99. http://dx.doi.org/10.5897/JMPR2015.6043 )
  • Achillea fragrantissima act as ACE inhibitor . --- (Fahad, M. (2017). Journal Of Medicinal Plants Research., 10(8), 93-99. http://dx.doi.org/10.5897/JMPR2015.6043 )
  • Rhazya stricta act as ACE inhibitor . --- (Fahad, M. (2017). Journal Of Medicinal Plants Research., 10(8), 93-99. http://dx.doi.org/10.5897/JMPR2015.6043 )

  •   ►  URL -- http://www.academicjournals.org/journal/JMPR/article-abstract/3FB279457381,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- IRON with Dietary Substance is Drug Enhancer, POTASSIUM with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.otto-wipfel.co.uk/otto/supplements-medication/DRUG-HERB-VITAMINS-INTERACTIONS-A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- MULATHI I.E LICORICE with Increase blood pressure & avoided by those taking blood pressure drugs., POTASSIUM with Increase the risk of hyperkalemia ., CAPSICUM with Cause risk of cough ,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand
  • Mohan, L. (2013). Antihypertensive Drugs Interaction with Herbal Medicine – Review. International Journal Of Pharmaceutical And Phytopharmacological Research (Eijppr), 3(2), 139-143.

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20, http://eijppr.com/vol3-issue2/eIJPPR-2013-3-2-139-143.pdf,

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1457   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   7 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1457   Edition : 37,