Lithium carbonate is a Medicine belongs to Mood Stabilizers group whose information about Brand can be referenced from   Book : Martindale    Page : 438   Edition : 37,

  ►   Brandname : Lithobid,Camcolit,Licab,Staleth,Lithicarb, Quilonum, Hypnorex

  ►  Strength : Capsule with 150  mg, Capsule with 300  mg, Capsule with 600  mg, Tablet with 300  mg, Syrup with 8/5  mEq/ml, sustained realease tablet with 300  mg, sustained realease tablet with 450  mg, Extended- release tablets with   , Prolonged-release tablets with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 519   Edition : 12, Martindale    Page : 438   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 436   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Oral 1 1.5 gm Tablet Camolit tablet (Norgine, UK): Dosse; Given daily; for prophylaxis, initially 300 to 400 mg daily.
2 Oral 450 675 mg Tablet b.d. Liskonum tablets (GlaxoSmithKline, UK): elderly; 225 mg twice daily, prophylaxis: 450 mg twice daily.
3 Oral 400 mg 1.2 gm Tablet Priadel tablets (Sanofi-Aventis, UK) Dose: Given daily, elderly or patients less than 50 kg, 200 to 400 mg daily.

Ref :-  Book : Martindale    Page : 437   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Lithium carbonate' drug in  Generalized, Tonic-Clonic Seizures  disease, then Please Not to be given .

Precaution :- If a Patient is using 'Lithium carbonate' drug in  acute kidney injury   disease, then Please contraindicated .

►  Side Effect : nausea, diarrhea, vertigo, muscle weakness, dazed feeling, Fine hand tremors, polyuria, polydipsia, weight gain, oedema, hypercalcaemia, hypercalcemia, hypermagnesaemia, acne, Rashes, leucocytosis, hypothyroidism, goitre, hyperthyroidism, psoriasis, ,
Ref :-   Book : Martindale    Page : 432   Edition : 37,

►  Drug Interaction : Drug interaction of Lithium carbonate is with NA

  ►    Mechanism of Drug Drug Interaction :  Some diuretics may reduce lithium excretion and result in toxicity. Thiazide diuretics may also show a paradoxical antidiuretic effect. Consequently, diuretics should be avoided or used with caution in those receiving lithium; if used together, a reduction in the lithium dose may be appropriate. Other drugs affecting electrolyte balance may also alter lithium excretion and should be avoided if possible or used with care,
Ref :-   Book : Martindale    Page : 435   Edition : 37,


►  Contraindication : Addison’s disease, Cardiac disease, renal impairment, pregnant women, Unterated hypothyroidism, Myasthenia gravis,
Ref :-   Book : Martindale    Page : 434   Edition : 37,
  ►  Mechanism of Action :   Lithium can mimic other monovalent cations and disrupt proteins and transporters that require cation cofactors. Lithium enters cells via Na+ channels. Lithium inhibits both the inositol phosphatase that dephosphorylates IP2 to inositol phosphate (IP1) and the inositol phosphatase that dephosphorylates IP1 to free inositol, thereby blocking the phosphatidylinositol signaling cascade in the brain. By blocking the regenration of PIP2, lithium inhibits central adrenergic, muscarinic, and serotonergic neurotransmission,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 224   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Vitex negundo with Another pathway, Fish with Another pathway, Egg with Another pathway, Beans with Another pathway,

  ►  Pathway with its reference as follows :-
  • Useful in the treatment of bipolar disorder . --- (Ahmed, M., & Kabidul Azam, M. (2014). Traditional Knowledge and Formulations of Medicinal Plants Used by the Traditional Medical Practitioners of Bangladesh to Treat Schizophrenia Like Psychosis. Schizophrenia Research And Treatment, 2014, 1-10. http://dx.doi.org/10.1155/2014/679810 )
  • Fish is rich in Omega-3 fatty acids which is useful in the treatment of biopolar disorder . --- (Qureshi, N., & Al-Bedah,. (2013). Mood disorders and complementary and alternative medicine: a literature review. Neuropsychiatric Disease And Treatment, 639. http://dx.doi.org/10.2147/ndt.s43419 )
  • Egg is rich in Cholin it is useful in the treatment of bipolar disorder . --- (Qureshi, N., & Al-Bedah,. (2013). Mood disorders and complementary and alternative medicine: a literature review. Neuropsychiatric Disease And Treatment, 639. http://dx.doi.org/10.2147/ndt.s43419 )
  • Beans is rich inositol it is useful in the treatment of bipolar disorder . --- (Qureshi, N., & Al-Bedah,. (2013). Mood disorders and complementary and alternative medicine: a literature review. Neuropsychiatric Disease And Treatment, 639. http://dx.doi.org/10.2147/ndt.s43419 )

  •   ►  URL -- https://www.hindawi.com/journals/schizort/2014/679810/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660126/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- CAFFEINE with Dietary Substance is Drug Inhibitor,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- MAGNESIUM with Increases blood folate level., POTASSIUM with Increases blood mineral level., IODINE with Impairs iodine metabolism., LOW SALT with low salt diet increases the risk of lithium toxicity.,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • "Introduction Food, Dietary Supplements And Their Components Can .". European Journal o f Clinical Pharmacology, n. pag. Print.

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf, http://shodhganga.inflibnet.ac.in/bitstream/10603/42594/5/05_chapter%201.pdf,

    ►   Route of Elimination :   Sweat, Saliva, Renal, Faecal,
    Ref :-   Book : Martindale    Page : 436   Edition : 37,


    ►    Plasma Half-life :   Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA