Lomefloxacin is a Medicine belongs to FLUOROQUINOLONES group whose information about Brand can be referenced from   Book : Martindale    Page : 319   Edition : 38,

  ►   Brandname : Lomef,Lomflox,Maxaquin

  ►  Strength : Tablet with 400  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 838   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, Topical,
Reference :-   Book : Martindale    Page : 321   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute uncomplicated cystitis Oral 400 mg Tablet o.d.
2 Surgical infection prophylaxis Oral 400 mg Tablet o.d.
3 Bacterial conjunctivitis Topical 3 % Eye Drop
4 Otitis externa Topical 0.3 % Ear Drop

Ref :-  Book : Martindale    Page : 319   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : Gastrointestinal upset, allergic reactions, rash, pruritus, arthralgia, anaphylaxis, diarrhea, Dizziness, headache, Confusion, convulsion, reversible arthropathy, rupture of tendons, corneal precipitates,
Ref :-   Book : Martindale    Page : 263,319   Edition : 38th,

►  Drug Interaction : Drug interaction of Lomefloxacin is with Sucralfate , Probenecid , Tiagabine, Oxcarbazepine , Zonisamide , Iron , Sildenafil ,
Ref :-   Book : Basic & Clinical pharmacology    Page : 1151,1158,1161   Edition : 12,


  ►    Mechanism of Drug Drug Interaction :  Sucralfate reduces gastrointestinal absorption of lomefloxacin, and probably other quinolones. Antacids may adsorb drugs in gastrointestinal tract, thus decreasing gastrointestinal absorption of lomefloxacin. Iron binds with quinolones in gastrointestinal tract, thereby reducing absorption of lomefloxacin and other quinolones. The excretion of lomefloxacin or related drugs is reduced and plasma concentrations may be increased by probenecid. Cations such as aluminium, calcium, magnesium, reduce the absorption of oral lomefloxacin or related drugs when given together.,
Ref :-   Book : Martindale    Page : 267,319   Edition : 38,


►  Contraindication : Pregnant and lactating women, myasthenia gravis, renal impairment, G6PD deficiency, Epilepsy,
Ref :-   Book : Martindale    Page : 264   Edition : 38,
  ►  Mechanism of Action :   The quinolone antibiotics target bacterial DNA gyrase and topoisomerase IV. For many gram-positive bacteria (such as S. aureus), topoisomerase IV is the primary activity inhibited by the quinolones. ,
Ref :-   Book : Goodman    Page : 1470   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Clove with Another pathway, Neem with Another pathway, Turmeric with Another pathway, Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • Clove having active compound eugenol which act as antibacterial effect . --- (Tiwari, V., Roy, R., & Tiwari, M. (2015). Antimicrobial active herbal compounds against Acinetobacter baumannii and other pathogens. Frontiers In Microbiology, 6. http://dx.doi.org/10.3389/fmicb.2015.00618 )
  • Neem having active compound nimbiol which act as antibacterial effect . --- ( Tiwari, V., Roy, R., & Tiwari, M. (2015). Antimicrobial active herbal compounds against Acinetobacter baumannii and other pathogens. Frontiers In Microbiology, 6. http://dx.doi.org/10.3389/fmicb.2015.00618 )
  • Turmeric having active compound curcumin which act as antibacterial . --- (Tiwari, V., Roy, R., & Tiwari, M. (2015). Antimicrobial active herbal compounds against Acinetobacter baumannii and other pathogens. Frontiers In Microbiology, 6. http://dx.doi.org/10.3389/fmicb.2015.00618 )
  • Garlic act as antibacterial effect . --- ( Tiwari, V., Roy, R., & Tiwari, M. (2015). Antimicrobial active herbal compounds against Acinetobacter baumannii and other pathogens. Frontiers In Microbiology, 6. http://dx.doi.org/10.3389/fmicb.2015.00618 )

  •   ►  URL -- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4471432/,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Fecal, Renal,
    Ref :-   Book : Martindale    Page : 321   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   7 hours,    Max value :-   8 hours,
    Ref :-   Book : Martindale    Page : 321   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   1.5 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 321   Edition : 38,