Loperamide is a Medicine belongs to Antidiarrheal group whose information about Brand can be referenced from   Book : Martindale    Page : 1894   Edition : 37,

  ►   Brandname : Chemists Own Diarrhoea Relief, Gastro-Stop, Harmonise, Boxolip, duralopid, Endialop, Diarlop, Lopamide, Arret, Diah-Limit, Diaquitte, Imodium, K-Pek II

  ►  Strength : Capsule with 2  mg, Tablet with 2  mg, Solution with 1/5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 1112   Edition : 12, Basic & Clinical pharmacology    Page : 1110   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1894   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute diarrhoea Oral 4 mg Followed by 2 mg after each loose stool to a maximum of 16 mg daily; the usual daily dose is 6 to 8 mg.
2 Chronic diarrhoea Oral 4 8 mg Dose: Given in daily divided doses subsequently adjusted as necessary; doses of 16 mg daily should not be exceeded. If no improvement has been seen after treatment with 16 mg daily for at least 10 days, further use is unlikely to be of benifit.
3 Acute diarrhoea Oral 2 4 mg Loperamide is also given as the prodrug, loperamide oxide, which is converted to loperamide in the gastrointestinal tract. Dose followed by 1 mg after each loose stool, to a maximum of 8 mg daily

Ref :-  Book : Martindale    Page : 1894   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Acute diarrhoea 4 Year 8 Year Oral 1 mg t.i.d/q.i.d
2 Acute diarrhoea 8Year Oral 2 mg q.i.d.
3 Chronic diarrhoea 1 Month 1 Year Oral 100 200 microgram/kg Tablet/Capsule b.d.
4 Chronic diarrhoea 1 Year 12 Year Oral 100 200 micrograms/kg Tablet/Capsule t.i.d/q.i.d
5 Chronic diarrhoea 12 Year 18 Year

Ref :- Book : Martindale    Page : 1894   Edition : 37,
Precaution :- If a Patient is using 'Loperamide' drug in  irritable bowel syndrome  disease, then Please not to give if constipation is present .

Precaution :- If a Patient is using 'Loperamide' drug in  acute gastroenteritis  disease, then Please decreases gastric motility so increased risk o infection .

Precaution :- If a Patient is using 'Loperamide' drug in ASCITES disease, then Please Use with caution. Can precipitate acute obstruction   if he ever suffered from DIARRHOEA disease.
►  Side Effect : abdominal pain, bloating, nausea, constipation, dry mouth, Dizziness, fatigue, hypersensitivity reactions, Skin rashes, paralytic ileus,
Ref :-   Book : Martindale    Page : 1893   Edition : 37,

►  Drug Interaction : Drug interaction of Loperamide is with Desmopressin , Itraconazole , Ritonavir, Gemfibrozil , cotrimoxazole, Quinidine ,
Ref :-   Book : Martindale    Page : 1893,1894   Edition : 37, Basic & Clinical pharmacology    Page : 1893,1894   Edition : 12,


  ►    Mechanism of Drug Drug Interaction :  Loperamide may increase the gastrointestinal absorption of desmopressin.,
Ref :-   Book : Martindale    Page : 1893   Edition : 37,


►  Contraindication : Ileus, Constipation, abdominal distension, Acute inflammatory bowel disease, antibiotic-associated colitis, dysentery, hepatic impairment,
Ref :-   Book : Martindale    Page : 1893   Edition : 37,
  ►  Mechanism of Action :   Loperamide is a synthetic derivative of pethidine that inhibits gut motility and may also reduce gastrointestinal secretions.,
Ref :-   Book : Martindale    Page : 1894   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- opium ie papaversomniferum with Another pathway,

  ►  Pathway with its reference as follows :-
  • Methylmorphine have antipsycotic effect --- ( Kokate, c. & Purohit, A. (2016). pharmacognosy. nirali prakashan )

  •   ►  URL -- https://www.sapnaonline.com/books/pharmacognosy-ck-kokate-8196396155-9788196396152,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- ACACIA ARABICA I.E BABOOL with Large dose lead to indigestion & constipation ,

      ►  Reference :-
  • PDR for Herbal medicines. (2000) (4th ed.). U.S.

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,

    ►   Route of Elimination :   Hepatic (Metabolism), Biliary, Faecal,
    Ref :-   Book : Martindale    Page : 1894   Edition : 37,


    ►    Plasma Half-life :   Min value :-   7 hours,    Max value :-   14 hours,
    Ref :-   Book : Goodman    Page : 505   Edition : 12,


    ►    Peak Plasma Concentration :   Min value :-   ~4 hours,    Max value :-   NA
    Ref :-   Book : Goodman    Page : 505   Edition : 12,