Lopinavir is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 989   Edition : 37, Martindale    Page : 989   Edition : 37,

  ►   Brandname : Kaletra,Aluvia,Ritomax-L

  ►  Strength : Capsule with 133.3/33.3  mg, Solution with 80/20  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 889   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 989   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info

Ref :-  Book :




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : diarrhoea, Pancreatitis, asthenia, headache, insomnia, Pain, paraesthesia, Gastrointestinal disturbances, acne, Rashes, Increases in serum cholesterol and triglycerides, ECG abnormalities, QT interval prolongation, torsade de pointes, Immune reconstitution syndrome,
Ref :-   Book : Martindale    Page : 989   Edition : 37,

►  Drug Interaction : Drug interaction of Lopinavir is with Rifampicin , Nevirapine, Efavirenz,
Ref :-   Book : Martindale    Page : 989   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Lopinavir is extensively metabolised by the cytochrome P450 isoenzyme CYP3A4. It is formulated with low-dose ritonavir, which inhibits this enzyme and thus increases exposure. The combination is an inhibitor of CYP3A4 and increases plasma concentration of drugs mainly metabolised by this isoenzyme. It has also been shown in vivo to induce its own metabolism and to increase the biotransformation of some drugs metabolised by cytochrome P450 isoenzymes and by glucuronidation. Drugs that strongly induce CYP3A4 may result in decreased plasma concentrations of the combination.,
Ref :-   Book : Martindale    Page : 989   Edition : 37,


►  Contraindication : pancreatitis, hepatic impairment, pregnancy, renal impairment,
Ref :-   Book : Martindale    Page : 989   Edition : 37,
  ►  Mechanism of Action :   It is a selective, competitive, reversible inhibitor of HIV-1 protease. It interferes with the formation of essential viral proteins making them incapable of infecting other cells.,
Ref :-   Book : Martindale    Page : 989   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- African potato with Another pathway,

  ►  Pathway with its reference as follows :-
  • antiretroviral . --- (Mills, E., & Cooper, C. (2005). African herbal medicines in the treatment of HIV: Hypoxis and Sutherlandia. An overview of evidence and pharmacology. Nutrition Journal, 4(19). )

  •   ►  URL -- https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-4-19,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Faecal,
    Ref :-   Book : Martindale    Page : 990   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   5 hours,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : 990   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   4 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 990   Edition : 37,