Loratadine is a Medicine belongs to Antihistamine (H1 blocker) group whose information about Brand can be referenced from   Book : Martindale    Page : 635   Edition : 37,

  ►   Brandname : Allernon, Clarityn, Lisino, Livotab, Clartin, Alavert, Claritin, Clear-Atadine, Non-Drowsy Allergy

  ►  Strength : Tablet with 10  mg, Chewable tablets with 5  mg, Disintegrating tablets with 10  mg, Syrup with 1  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 635   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Allergic conditions Oral 10 mg o.d. Dose: alternatively, 5 mg every 12 hours may be given

Ref :-  Book : Martindale    Page : 635   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Allergic conditions 2 Year 5 Year Oral 5 mg o.d.
2 Allergic conditions 6 Year

Ref :- Book : Martindale    Page : 635   Edition : 37,
►  Side Effect : Non-sedating antihistamines is that most have little or no antimuscarinic effect, nausea, vomiting, diarrhoea, epigastric pain, palpitations, Arrhythmias, Rashes, hypersensitivity reactions, bronchospasm, angioedema, anaphylaxis, convulsion, sweating, myalgia, paraesthesia, extrapyramidal effects, tremor, Sleep disturbances, Depression, Confusion, tinnitus, hypotension, hair loss, ,
Ref :-   Book : Martindale    Page : 611,635   Edition : 37,

►  Drug Interaction : Drug interaction of Loratadine is with Fluoxetine , Fluconazole , Quinidine , Ketoconazole , Erythromycin , Cimetidine ,
Ref :-   Book : Martindale    Page : 613,635   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Potentially hazardous ventricular arrhythmias have occurred when the non-sedating antihistamines have been given with drugs liable to interfere with their hepatic metabolism, with other potentially arrhythmogenic drugs including those that prolong the QT interval, or with those likely to cause electrolyte imbalance. Loratadine is metabolised by cytochrome P450 isoenzymes CYP3A4 and CYP2D6. Therefore use with other drugs that inhibit or are metabolised by these hepatic enzymes may result in changes in plasma concentrations of either drug and, possibly, adverse effects. Drugs known to inhibit one or other of these enzymes include cimetidine, erythromycin, ketoconazole, quinidine, fluconazole, and fluoxetine.,
Ref :-   Book : Martindale    Page : 613,635   Edition : 37,


►  Contraindication : In the case of non-sedating antihistamines, although drowsiness is rare, it can occur and may affect the performance of skilled tasks, Convulsions, Caution in patients with epilepsy, renal impairment, hepatic impairment, Increase the risk of arrhythmias, known or suspected prolongation of the QT interval, Hypokalaemia, electrolyte imbalance, It should be avoided in neonates, young children, elderly patients,
Ref :-   Book : Martindale    Page : 612,635   Edition : 37,
  ►  Mechanism of Action :   Inverse agonists that bind preferentially to the inactive conformation of the H1 receptor and shift the equilibrium toward the inactive receptor state,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 775   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Onion with same compound,

  ►  Pathway with its reference as follows :-
  • Antihistamine H₁-receptor blocker used to treat allergies --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Faecal,
    Ref :-   Book : Martindale    Page : 635   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   8.4 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 635   Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 635   Edition : 37,