Lorazepam is a Medicine belongs to Benzodiazepine group whose information about Brand can be referenced from   Book : Martindale    Page : 1109   Edition : 37,

  ►   Brandname : Ativan, duralozam, Laubeel, Calmese, Larpose

  ►  Strength : Tablet with 0.5  mg, Tablet with 1  mg, Tablet with 2  mg, Injection with 2  mg/ml, Injection with 4  mg/ml, Solution with 2  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 387   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV, IM,
Reference :-   Book : Martindale    Page : 1108-1109   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Anxiety Oral 1 6 mg Tablet Given daily in 2 or 3 divided doses with the largest dose taken at night; up to 10 mg daily has been given
2 Acute anxiety 25 30 micrograms/kg Injection Given every 6 hours
3 Panic disorder Oral 3 5 mg Tablet Dose: Given daily.
4 Insomnia Oral 1 4 mg Tablet Dose: For insomnia associated with anxiety: Given at bedtime
5 Premedication Oral 2 3 mg Tablet Dose: Given at night before the operation.
6 Premedication IM or IV 50 micrograms/kg Injection Dose: Given 30 to 40 minutes before the operation if given intravenously or 1 to 11/2 hours before if given intramuscularly
7 Status epilecticus IV 4 mg Injection Dose: This may be repeated once after 10-15 minutes if seizures recur
8 Prophylaxis of nausea and vomitting Oral 1 2 mg Tablet In patients receiving modestly emetogenic chemotherapy, lorazepam 1 to 2 mg orally may be added to antiemetic therapy with domperidone or metoclopramide

Ref :-  Book : Martindale    Page : 1109   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Premedication 1 Month 12 Year Oral 50 100 micrograms/kg Tablet
2 Premedication Oral 1 4 mg Tablet
3 Premedication 1 Month 18 Year slow i.v 50 100 micrograms/kg Injection
4 Status epilepticus IV 2 mg Injection
5 Status epilepticus slow i.v 100 micrograms/kg Injection
6 Status epilecticus slow i.v 100 micrograms/kg Injection

Ref :- Book : Martindale    Page : 1109   Edition : 37,
►  Side Effect : Pain and a sensation of burning have occured after injection, drowsiness, Sedation, muscle weakness, ataxia, vertigo, headache, Confusion, Depression, slurred speech, dysarthria, changes in libido, tremor, visual disturbances, urinary retention, urinary incontinence, gastrointestinal disturbance, changes in salivation, amnesia, paradoxical excitation, raised liver enzyme values, respiratory depression, ,
Ref :-   Book : Martindale    Page : 1090,1108   Edition : 37,

►  Drug Interaction : Drug interaction of Lorazepam is with opioid analgesics, , General anaesthetics , Antipsychotic , Sedative antihistamines, antidepressants, Alcohol,  NA

  ►    Mechanism of Drug Drug Interaction :  Enhanced sedation or respiratory and cardiovascular depression may occur if diazepam or other benzodiazepines are given with other drugs that have CNS depressant properties; these include alcohol, antidepressants, sedative antihistamines, antipsychotics, general anaesthetics, other hypnotics or sedatives, and opioid analgesics. The metabolism of most banzodiazipines is mediated primarily by the cytochrome P450 system, particularly the isoenzymes CYP2C19 and CYP3A4. Hence, adverse effects may also be produce by use with drugs that inhibit or induce or metabolized by these isoenzymes. Benzodiazepines such as diazepam that are metabolised primarily by hepatic microsomal oxidation may be more susceptible to pharmacokinetic changes than those eliminated primarily by glucuronide conjugation.,
Ref :-   Book : Martindale    Page : 1093,1108   Edition : 37,


►  Contraindication : hepatic impairment, Myasthenia gravis, pre-existing CNS depression or coma, respiratory depression, acute pulmonary insufficiency, renal impairment, sleep apnoea, chronic pulmonary insufficiency, Lorazepam is not appropriate for the treatment of chronic psychosis or for phobic or obsessional states, Caution is required in patients with organic brain changes particularly arteriosclerosis,
Ref :-   Book : Martindale    Page : 1092,1108   Edition : 37,
  ►  Mechanism of Action :   Potentiate GABA-mediated inhibition to increase chloride current through the channel ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 238   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Valerian with Another pathway, Valerian with Another pathway,

  ►  Pathway with its reference as follows :-
  • Anti-anxiety --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )
  • Antipsychotic --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale, http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- with Puerarin reduce the effect of lorazepam,

      ►  Reference :-
  • Eldelberg, D. The New Age of nutritional and herbal remedies. New Zealand

  •   ►  URL -- https://books.google.co.in/books?id=WZhj8EO9N3sC&pg=PA49&lpg=PA49&dq=The+New+Age+of+nutritional+and+herbal+remedies.++book&source=bl&ots=UVld-vNZL0&sig=5KwkKUUvW45p0TkfVUCtMZxnbow&hl=en&sa=X&ved=0ahUKEwiajLCNocrOAhVMto8KHfD2D-4Q6AEIMDAE#v=onepage&q=The%20,

    ►   Route of Elimination :   Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 1108   Edition : 37,


    ►    Plasma Half-life :   Min value :-   10 hours,    Max value :-   20 hours,
    Ref :-   Book : Martindale    Page : 1108   Edition : 37,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1108   Edition : 37,