Losartan is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1460   Edition : 37,

  ►   Brandname : Cozaar,Alsartan,Covance,Lara,Losacar

  ►  Strength : Tablet with 25  mg, Tablet with 50  mg, Tablet with 100  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 190   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1459   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 hypertension Oral 50 mg Tablet o.d. The dose may be increased, if necessary, to 100 mg daily as a single dose or in two divided doses. An initial dose of 25 mg once daily should be given to patients with intravascular fluid depletion, and to those with hepatic impairment.
2 Heart failure Oral 12.5 mg Tablet o.d. For those aged 60 years and over: Dose may be doubled at weekly intervals to a usual maintenance dose of 50 mg once daily.
3 Diabetic nephropathy Oral 50 mg Tablet o.d. Dose: Increased to 100 mg once daily depending on the blood pressure.

Ref :-  Book : Martindale    Page : 1459   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 hypertension 6 Year 20 to 50 kg Oral 700 micrograms/kg Tablet
2 hypertension 6Year Over 50 kg Oral 1.4 mg/kg Tablet

Ref :- Book : Martindale    Page : 1459   Edition : 37,
►  Side Effect : Dizziness, headache, Impaired renal function, hyperkalaemia, myalgia, arthralgia, respiratory-tract disorders, back pain, gastrointestinal disturbance, fatigue, neutropenia, Dose-related orthostatic hypotension, ,
Ref :-   Book : Martindale    Page : 1458   Edition : 37,

►  Drug Interaction : Drug interaction of Losartan is with NSAIDS, , Potassium -Sparing Diuretics , ,  NA

  ►    Mechanism of Drug Drug Interaction :  The antihypertensive effects of losartan may be potentiated by drugs or other agents that lower blood pressure. An additive hyperkalaemic effect is possible with potassium supplements, potassium-sparing diuretics, or other drugs that can cause hyperkalaemia; losartan and potassium-sparing diuretics should not generally be given together. NSAIDs should be used with caution in patients taking losartan as the risk of renal impairment may be increased, particularly in those who are inadequately hydrated; use of NSAIDs may also attenuate the hypotensive effect of losartan. Losartan and some other angiotensin II receptor antagonists are metabolised by cytochrome P450 isoenzymes and interactions may occur with drugs that affect these enzymes.,
Ref :-   Book : Martindale    Page : 1458   Edition : 37,


►  Contraindication : pregnancy, Renal artery stenosis, Severe hepatic impairment, renal impairment,
Ref :-   Book : Martindale    Page : 1458   Edition : 37,
  ►  Mechanism of Action :   Losartan is an angiotensin II receptor antagonist with antihypertensive activity due mainly to selective blockade of AT1 receptors and the consequent reduced pressor effect of angiotensin II.,
Ref :-   Book : Martindale    Page : 1459   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- POTASSIUM with Increase in Nutrient Level,

  ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,


    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Hepatic (Metabolism), Biliary, Renal, Faecal,
    Ref :-   Book : Martindale    Page : 1459   Edition : 37,


    ►    Plasma Half-life :
      Min value :-   1.5 hours,    Max value :-   2.5 hours,
    Ref :-   Book : Martindale    Page :    Edition : 37,

    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1459   Edition : 37,