Lovastatin is a Medicine belongs to Agent used in Dyslipidemia group whose information about Brand can be referenced from   Book : Martindale    Page : 1461   Edition : 37,

  ►   Brandname : Alltopreb, Mevacor, Lovacard, Pro HDL, Rovacor, Lova, Lovabeta

  ►  Strength : Tablet with 10  mg, Tablet with 20  mg, Tablet with 40  mg, Extended- release tablets with 20  mg, Extended- release tablets with 40  mg, Extended- release tablets with 60  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 633   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1461   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Hyperlipidaemia Oral 10 20 mg Tablet Dose: Given daily in the evening with food, increased, if necessary, at intervals of 4 weeks or more to 80 mg daily as a single dose or in 2 divided doses.

Ref :-  Book : Martindale    Page : 1461   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Hyperlipidaemia 10 Year 17 Year Oral 10 20 mg Tablet o.d.

Ref :- Book : Martindale    Page : 1461   Edition : 37,
Precaution :- If a Patient is using 'Lovastatin' drug in acute kidney injury disease, then Please use with caution   if he ever suffered from MYOCARDIAL ISCHEMIA disease.
►  Side Effect : gastrointestinal disturbance, headache, Skin rashes, Dizziness, Blurred Vision, insomnia, Dysgeusia, hepatitis, Pancreatitis, hypersensitivity reactions, anaphylaxis, angioedema, myalgia, muscle weakness, ,
Ref :-   Book : Martindale    Page : 1460,1526   Edition : 37,

►  Drug Interaction : Drug interaction of Lovastatin is with , HIV- protease inhibitors, ,  Verapamil , Amiodarone , Danazol, Nefazodone, Telithromycin, Clarithromycin , Erythromycin , Ketoconazole , Itraconazole ,
Ref :-   Book : Martindale    Page : 1461,1528   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  it is metabolised by the cytochrome P450 isoenzyme CYP3A4, as are atorvastatinand lovastatin, and interactions may occur with drugs that inhibit this enzyme, including ciclosporin, itraconazole, ketoconazole, erythromycin, clarithromycin, telithromycin, HIV-protease inhibitors, nefazodone, danazol, amiodarone, and verapamil; there may also be a similar interaction with grapefruit juice. ,
Ref :-   Book : Martindale    Page : 1461,1528   Edition : 37,


►  Contraindication : hepatic disease, renal impairment, Pregnancy,
Ref :-   Book : Martindale    Page : 1460,1527-1528   Edition : 37,
  ►  Mechanism of Action :   Lovastatin is a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase), the ratedetermining enzyme for cholesterol synthesis. Inhibition of HMG-CoA reductase leads to reduced cholesterol synthesis in the liver and lower intracellular cholesterol concentrations; this stimulates an increase in low-density-lipoprotein (LDL)-cholesterol receptors on hepatocyte membranes, thereby increasing the clearance of LDL from the circulation. HMG-CoA reductase inhibitors (also called statins) reduce total cholesterol, LDL-cholesterol, and very-low-density lipoprotein (VLDL)-cholesterol concentrations in plasma. They also tend to reduce triglycerides and to increase high-density lipoprotein (HDL)-cholesterol concentrations. ,
Ref :-   Book : Martindale    Page : 1461,1530   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Angeer with Another pathway,

  ►  Pathway with its reference as follows :-
  • Hypolipidemic effect. --- (Joseph, Baby. "Pharmacognostic And Phytochemical Properties Of Ficus Carica Linn –An Overview". International Journal of PharmTech Research 3.1 (2017): 08-12,. Print. )

  •   ►  URL -- http://sphinxsai.com/Vol.3No.1/pharm_jan-mar11/pdf/JM11(%20PT=03)%2008-12.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- COQ10 with Impairs coenzyme Q10 metabolism .,

      ►  Reference :-
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- http://197.14.51.10:81/pmb/AGROALIMENTAIRE/Handbook%20of%20Nutrition.pdf,

    ►   Route of Elimination :   Biliary, Renal, Faecal,
    Ref :-   Book : Martindale    Page : 1461   Edition : 37,


    ►    Plasma Half-life :   Min value :-   1 hours,    Max value :-   3 hours,
    Ref :-   Book : Basic & Clinical pharmacology    Page : 626   Edition : 12,


    ►    Peak Plasma Concentration :   Min value :-   2 hours,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 1461   Edition : 37,