Loxapine is a Medicine belongs to Antipsychotic group whose information about Brand can be referenced from   Book : Martindale    Page : 1110   Edition : 37,

  ►   Brandname : Loxitane,Loxapac

  ►  Strength : Capsule with 5  mg, Capsule with 10  mg, Capsule with 25  mg, Capsule with 50  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 519   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IM,
Reference :-   Book : Martindale    Page : 1110   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Psychoses including schizophrenia Oral 20 50 mg Capsule Dose: in 2 divided doses, increased according to response over the next 7 to 10 days to 60 to 100 mg daily or more, in 2 to 4 divided doses; the maximum recommended dose is 250 mg daily
2 Psychoses including schizophrenia IM 300 mg Injection Dose: For the control of acute conditions: Given in 2 or 3 divided doses

Ref :-  Book : Martindale    Page : 1110   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
►  Side Effect : nausea, vomiting, seborrhoea, dyspnoea, ptosis, headache, paraesthesia, facial flush, weight gain, weight loss, polydipsia, dry mouth, constipation, difficulty in micturition, Blurred Vision, mydriasis, tachycardia, ECG changes, hypotension, delirium, agitation, hypersensitivity reactions, Urticaria, exfoliative dermatitis, erythema multiforme, contact sensitivity, jaundice, photosensitivity reactions, haemolytic anaemia, aplastic anaemia, thrombocytopenic purpura, eosinophilia, fatal agranulocytosis, ,
Ref :-   Book : Martindale    Page : 1072, 1110   Edition : 37,

►  Drug Interaction : Drug interaction of Loxapine is with Tricyclic antidepressants, Diuretics, Antimalarials, , , , , Opioids, Anxiolytics, Hypnotics, General anaesthetics , Alcohol,  Cisapride ,
Ref :-   Book : Martindale    Page : 1076,1110   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  Symptoms of CNS depression may be enhanced by other drugs with CNS-depressant properties including alcohol, general anaesthetics, hypnotics, anxiolytics, and opioids. When given with other drugs that produce orthostatic hypotension, dosage adjustments may be necessary. There is an increased risk of arrhythmias when antipsychotics are used with drugs that prolong the QT interval, including certain antiarrhythmics, other antipsychotics, some non-sedating antihistamines, antimalarials, and cisapride; use with diuretics that cause electrolyte imbalance (particularly hypokalaemia) may also have the same effect. There is also an increased risk of arrhythmias when tricyclic antidepressants are used with antipsychotics that prolong the QT interval.,
Ref :-   Book : Martindale    Page : 1076,1110   Edition : 37,


►  Contraindication : pre-existing CNS depression or coma, Bone marrow suppression, phaeochromocytoma, Prolactin dependent tumor, hepatic impairment, renal impairment, Cardiovascular impairment, Cerebrovascular impairment, Respiratory function impairment, angle-closure glaucoma, History of jaundice, parkinsonism, Diabetes mellitus, Hypothyroidism, myasthenia gravis, paralytic ileus, prostatic hyperplasia, urinary retention,
Ref :-   Book : Martindale    Page : 1074,1110   Edition : 37,
  ►  Mechanism of Action :   Antagonize mesolimbic, and possibly mesocortical, D2 receptors; adverse effects are likely mediated by binding to D2 receptors in basal ganglia (nigrostriatal pathway) and pituitary gland. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 204   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Poppy seed with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antipsychotic --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- AGNUS CASTUS I.E. NIRGANDHI with Nirgandhi interact with dopamine antagosit drug,

      ►  Reference :-
  • Driver, S. (2009). Stockleys Herbal Medicines Interactions. Royal pharmaceutical Society of Great Britain: Pharmaceutical press.

  •   ►  URL -- https://www.stonybrookmedicine.edu/sites/default/files/herbal_medicines_interactions-1.pdf,

    ►   Route of Elimination :   Renal, Faecal,
    Ref :-   Book : Martindale    Page : 1110   Edition : 37,


    ►    Plasma Half-life :   Min value :-   nf,    Max value :-   NA
    Ref :-   Book :    Page :    Edition : ,


    ►    Peak Plasma Concentration :   Min value :-   1 hours,    Max value :-   2 hours,
    Ref :-   Book : Martindale    Page : 1110   Edition : 37,