Lypressin is a Medicine belongs to Antidiuretics group whose information about Brand can be referenced from   Book : Martindale    Page : 2652   Edition : 37,

  ►   Brandname : Pitressin,Pitressin Synthetic

  ►  Strength : Injection with   , Nasal Spray with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 2651   Edition : 37,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IM, SC, IV, intranasal,
Reference :-   Book : Martindale    Page : 2651   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Cranial diabetes insipidus S.C/I.M 5 20 units Injection Dose: Given every 4 hours.
2 Variceal bleeding IV 20 units Injection Dose: Given in 100 mL of glucose 5% infused intravenously over 15 minutes.

Ref :-  Book : Martindale    Page : 2651   Edition : 37,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Acute massive haemorrhage 1 Month 18 Year IV infusion 0.3 units/kg Injection

Ref :- Book : Martindale    Page : 2651   Edition : 37,
►  Side Effect : marked pallor, pounding headache, vertigo, sweating, tremor, nausea, vomiting, diarrhoea, eructation, uterine cramps, hyponatraemia, water intoxication, hypersensitivity reactions, anaphylactic shock, cardiac arrest, chest pain, myocardial ischaemia, arrhythmia, bradycardia, hypertension, gangrene, local irritation at the injection site, nasal congestion, Irritation, ulceration, thrombosis, Urticaria, bronchoconstriction, myocardial infarction,
Ref :-   Book : Martindale    Page : 2650-2651   Edition : 37,

►  Drug Interaction : Drug interaction of Lypressin is with Ganglion Blockers, Tricyclic antidepressants, ,  Chlorpropamide , Clofibrate, Carbamazapine , Fludrocortisone , Urea , Heparin , Demeclocycline , Noradrenaline/Norepinephrine ,
Ref :-   Book : Martindale    Page : 2651   Edition : 37,


  ►    Mechanism of Drug Drug Interaction :  The antidiuretic effects of vasopressins might be expected to be enhanced in some patients receiving chlorpropamide, clofibrate, carbamazepine, fludrocortisone, urea, or tricyclic antidepressants. Lithium, heparin, demeclocycline, noradrenaline, and alcohol may decrease the antidiuretiv effect. Ganglion-blocking drugs may increase sensitivity to the pressor effects of vasopressins,
Ref :-   Book : Martindale    Page : 2651   Edition : 37,


►  Contraindication : Patients with chronic nephritis with nitrogen retention, Vascular disease, especially of the coronary arteries, It should be given with care to patients with conditions which might be aggravated by water retention including asthma, epilepsy, migraine, and heart failure, Nasal absorption of vasopressin may be impaired in patients with rhinitis,
Ref :-   Book : Martindale    Page : 2651   Edition : 37,
  ►  Mechanism of Action :   It is secreted by the hypothalamus and stored in the posterior lobe of the pituitary gland. It may be prepared from the gland of mammals or by synthesis. It has a direct antidiuretic action on the kidney, increasing tubular reabsorption of water. It also constricts peripheral blood vessels and causes contraction of the smooth muscle of the intestine, gallbladder, and urinary bladder. It has practically no oxytocic activity.,
Ref :-   Book : Martindale    Page : 2651   Edition : 37,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- beetroot with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antidiuretic Property --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA