Magnesium/Magnesium Sulphate is a Medicine belongs to Electrolytes group whose information about Brand can be referenced from   Book : Martindale    Page : 1790   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Chloromag; Mag; Magneon; Kest,Mag-G,Mag-SR,A to Z,Calcimax,Calcimax Forte

  ►  Strength : Injection with 125  mg/ml, Injection with 500  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 250   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion, IM, Oral,
Reference :-   Book : Martindale    Page : 1788   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Acute or severe hypomagnesaemia IV infusion 20 mmol Injection In 1 litre of infusion solution (glucose 5% or sodium chloride 0.9%) given intravenously over 3 hours.
2 Severe magnesium deficiency IM 1 mmol/kg Injection Given over a period of 4 hours.
3 Antacid Oral 5 10 gm In 250 mL of water being given for rapid bowel evacuation.
4 Arrhythmias IV 2 gm Injection Over 10 to 15 minutes.
5 Seizures in pregnant women with eclampsia IV 4 gm Injection Given over 10 to 15 min.

Ref :-  Book : Martindale    Page : 1788   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  

Ref :- Book :
Precaution :- If a Patient is using 'Magnesium/Magnesium Sulphate' drug in  ACHALASIA  disease, then Please Contraindication .

Precaution :- If a Patient is using 'Magnesium/Magnesium Sulphate' drug in  preeclampsia  disease, then Please Poor reflexes, magnesium toxicity, confusion .

Precaution :- If a Patient is using 'Magnesium/Magnesium Sulphate' drug in  MYASTHENIA GRAVIS  disease, then Please Use with caution ( decreases acetycholine release) .

Precaution :- If a Patient is using 'Magnesium/Magnesium Sulphate' drug in  eclampsia  disease, then Please contraindication : H/O myaesthenia gravis. .

Precaution :- If a Patient is using 'Magnesium/Magnesium Sulphate' drug in  preeclampsia  disease, then Please Myasthenia Gravis, impaired Renal function .

►  Side Effect : hypermagnesaemia, respiratory depression, loss of deep tendon reflexes, neuromuscular blockade, nausea, vomiting, Flushing of the skin, thirst, hypotension, peripheral vasodilatation, drowsiness, Confusion, slurred speech, double vision, muscle weakness, bradycardia, coma, cardiac arrest,
Ref :-   Book : Martindale    Page : 1789   Edition : 38,

►  Drug Interaction : Drug interaction of Magnesium/Magnesium Sulphate is with , AMINOGLYCOSIDES , competitive and depolarising neuromuscular blockers. ,  Tetracycline , Nifedipine ,
Ref :-   Book : Martindale    Page : 1790   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Parenteral magnesium sulfate potentiates the effects of competitive and depolarising neuromuscular blockers. The neuromuscular blocking effects of parenteral magnesium and aminoglycoside antibacterials may be additive. Similarly, parenteral magnesium sulfate and nifedipine have been reported to have additive effects. Oral magnesium salts decrease the absorption of tetracyclines and bisphosphonates, and doses should be separated by a number of hours. ,
Ref :-   Book : Martindale    Page : 1790   Edition : 38,


►  Contraindication : heart block , severe renal impairment, Myasthenia gravis, use within 2 hours of delivery should be avoided,
Ref :-   Book : Martindale    Page : 1790   Edition : 38,
  ►  Mechanism of Action :   Inhibit calcium transport into smooth muscle cells, thereby inducing smooth muscle relaxation.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 835   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- with Another pathway,

  ►  Pathway with its reference as follows :-
  • Valeremic acid have Anticonvulsant activity --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://www.vitorrentz.in/search/Text+Book+Of+Pharmacognosy, +C.+K.+Kokate, +A.P.+Purohit, +S.B.+Gokhale,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 1790   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA