Mannitol is a Medicine belongs to Cardiovascular drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 1429   Edition : 38,

  ►   Brandname : Neurotol-M; Aridol,Osmitrol,Brochitol,Osmohale

  ►  Strength : Injection with   , Powder with   , Solution with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 1428   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion, inhalation, Oral,
Reference :-   Book : Martindale    Page : 1428   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Raised intra-ocular pressure IV infusion 0.25 2 gm/kg Injection Over 30 to 60 minutes.
2 Oliguric phase of renal failure IV infusion 50 100 gm Injection Given in 15 to 25% solution In 24 hour period.
3 Transurethral prostatic resection 2.5 5 % Solution

Ref :-  Book : Martindale    Page : 1428   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Oliguric phase of renal failure IV infusion 0.25 2 gm/kg Injection
2 Raised Intracranial Pressure or Intraoccual Pressure IV infusion 1 2 gm/kg Injection
3 PERIPHERAL OEDEMA 1 Month 18 Year IV infusion 1 2 gm/kg Injection

Ref :- Book : Martindale    Page : 1428   Edition : 38,
Precaution :- If a Patient is using 'Mannitol' drug in  acute kidney injury   disease, then Please .

►  Side Effect : nausea, vomiting, thirst, headache, Dizziness, chill, fever, tachycardia, chest pain, hyponatraemia, dehydration, Blurred Vision, Urticaria, hypotension, hypertension, , hypersensitivity reactions, oedema, skin necrosis, thrombophlebitis, diarrhoea, bronchospasm, Cough, wheezing, local irritation, Pain, Haemoptysis,
Ref :-   Book : Martindale    Page : 1428   Edition : 38,

►  Drug Interaction : Drug interaction of Mannitol is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : should not be given with whole blood., In patients with pulmonary congestion, Frank pulmonary oedema, intracranial bleeding (except during craniotomy), heart failure and severe dehydration.,
Ref :-   Book : Martindale    Page : 1428   Edition : 38,
  ►  Mechanism of Action :   Physical osmotic effect on tissue water distribution because it is retained in the vascular compartment,
Ref :-   Book : Basic & Clinical pharmacology    Page : 269   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Cucumber with Another pathway, Watermelon with same pathway, Carrot with Another pathway,

  ►  Pathway with its reference as follows :-
  • Diuretic properties --- (Maheshwari, R. (2014). nvigorating Efficacy of Cucumis Sativas for Healthcare. International Journal Of Chemistry And Pharmaceutical Science, 2(3), 737-744. )
  • High water content --- ( F.S,, O. (2014). Effect of Watermelon (citrullus lanatus) on pulse rate and blood pressure in healthy individuals. IOSR Journal Of Dental And Medical Sciences (IOSR-JDMS), 13(2279-0861.), 66-69. )
  • Diuretic properties --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.pharmaresearchlibrary.com/wp-content/uploads/2014/04/IJCPS2001.pdf, http://www.iosrjournals.org/iosr-jdms/papers/Vol13-issue3/Version-3/N013336669.pdf, http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 1429   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   100 Minutes,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 1429   Edition : 38 ,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA