Maraviroc is a Medicine belongs to Antiviral group whose information about Brand can be referenced from   Book : Martindale    Page : 1004   Edition : 38,

  ►   Brandname : Selzentry; Selsemtri

  ►  Strength : Tablet with 150  mg, Tablet with 300  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 888   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 1003   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 HIV infection Oral 300 mg Tablet b.d.

Ref :-  Book : Martindale    Page : 1003   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Antiretroviral therapy more than 16 Year Oral 150 mg Tablet b.d.
2 Antiretroviral therapy Oral 300 mg Tablet b.d.
3 Antiretroviral therapy Oral 600 mg Tablet b.d.

Ref :- Book : Nelson's textbook of Pediatrics    Page : 1171   Edition : 19,
►  Side Effect : Asthenia, cough, upper respiratory-tract infections, dizziness, abdominal pain, distension, constipation, diarrhoea, dyspepsia, nausea, vomiting, fever, headache, insomnia, somnolence, muscle spasms back pain, pruritus, and rash. , Less frequently reported adverse effects include Myositis, Rhabdomyolysis, osteonecrosis and cardiovascular effects such as myocardial ischaemia and myocardial infarction, , cardiac adverse effects were reported mainly for patients with pre-existing cardiac disease or risk factors., , hepatotoxicity, systemic allergic reaction,
Ref :-   Book : Martindale    Page : 1003   Edition : 38,

►  Drug Interaction : Drug interaction of Maraviroc is with ,  Rifampicin , Nefazodone, Clarithromycin , Itraconazole , Ketoconazole , Efavirenz, Tipranavir,
Ref :-   Book : Martindale    Page : 1003   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Maraviroc is a substrate for the cytochrome P450 isoenzyme CYP3A4 and for P-glycoprotein. Inhibitors of CYP3A4, such as HIV-protease inhibitors (other than tipranavir), increase the serum concentration of maraviroc. Inducers of CYP3A4 such as efavirenz may decrease serum maraviroc concentrations. Non-antiretroviral medications that significantly alter maraviroc metabolism include the CYP3A4 inhibitors ketoconazole, itraconazole, clarithromycin, and nefazodone and the CYP3A4 inducers rifampicin and St John’s wort. ,
Ref :-   Book : Martindale    Page : 1003   Edition : 38,


►  Contraindication : patients with pre-existing liver dysfunction or co-infection with hepatitis B or C., renal impairment,
Ref :-   Book : Martindale    Page : 1003   Edition : 38,
  ►  Mechanism of Action :   Maraviroc is a small-molecule antagonist of the CCR5 chemokine receptor; the drug blocks cellular infection of HIV strains that use CCR5 for attachment and entry.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 653   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- African potato with Another pathway,

  ►  Pathway with its reference as follows :-
  • Antiretroviral --- (Mills E, Cooper C, Seely D, Kanfer I. African herbal medicines in the treatment of HIV: Hypoxis and Sutherlandia. An overview of evidence and pharmacology. Nutrition Journal. 2005;4(1). )

  •   ►  URL -- https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-4-19,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal, Faecal,
    Ref :-   Book : Martindale    Page : 1004   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   0.5 ,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 1004   Edition : 38,