Mebendazole is a Medicine belongs to Antihelminthic Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 160   Edition : 38,

  ►   Brandname : Vermox,Mebex,Wormin

  ►  Strength : Tablet with 100  mg, Suspension with 100/5  mg/ml,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 946   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Basic & Clinical pharmacology    Page : 946   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Capillariasis Oral 200 mg Tablet b.d. 20 days.
2 Enterobiasis Oral 100 mg Tablet As a single dose, repeated if necessary after 2 to 3 weeks.
3 Ascariasis Oral 100 mg Tablet b.d. For 3 days.
4 Hookworm infections Oral 100 mg Tablet b.d. For 3 days.
5 Trichuriasis Oral 100 mg Tablet b.d. For 3 days.
6 Mass treatment control Oral 500 mg Tablet Single dose 4 times a year.

Ref :-  Book : Martindale    Page : 159   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Capillariasis more than 2 Year Oral 200 mg Tablet b.d.
2 Trichuriasis over than 1 Year Oral 100 mg Tablet b.d.
3 Enterobiasis more than 2 Year Oral 100 mg Tablet
4 Ascariasis over than 1 Year Oral 100 mg Tablet b.d.
5 Hookworm infections more than 1 Year Oral 100 mg Tablet b.d.

Ref :- Book : Martindale    Page : 159   Edition : 38,
►  Side Effect : headache, Dizziness, allergic reaction, raised hepatic enzymes, alopecia, bone marrow depression,
Ref :-   Book : Martindale    Page : 159   Edition : 38,

►  Drug Interaction : Drug interaction of Mebendazole is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : Patients given high doses of mebendazole, such as those with echinococcosis, should be supervised closely with blood counts and liver function being monitored; such high-dose therapy may be inappropriate in those with hepatic impairment,
Ref :-   Book : Martindale    Page : 159   Edition : 38,
  ►  Mechanism of Action :   The primary mechanism of action of BZ is thought to be inhibition of microtubule polymerization by binding to Beta-tubulin . The selective toxicity of these agents against helminths results from their higher affinity for parasite -tubulin than for the same target in higher eukaryotes. A range of other biochemical changes are found in nematodes following BZ exposure, including inhibition of mitochondrial fumarate reductase, reduced glucose transport, and uncoupling of oxidative phosphorylation.,
Ref :-   Book : Goodman    Page : 1450   Edition : 12,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Garlic with Another pathway,

  ►  Pathway with its reference as follows :-
  • Allicin have Anthelmintic effect --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Biliary, Hepatic (Metabolism), Renal,
    Ref :-   Book : Martindale    Page : 160   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   3,    Max value :-   6 hours,
    Ref :-   Book : Martindale    Page : 160   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   1.5,    Max value :-   7.25 hours,
    Ref :-   Book : Martindale    Page : 160   Edition : 38,