Meclozine (Meclizine) is a Medicine belongs to antihistamines group whose information about Brand can be referenced from   Book : Martindale    Page : 635   Edition : 38,

  ►   Brandname : Antivert,Antrizine,Bonine,Dizmiss,Dramamine,Meni-D

  ►  Strength : Tablet with 50  mg, Tablet with 25  mg, Tablet with 12.5  mg, Chewable tablets with 25  mg, Capsule with 25  mg,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 292   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, rectal,
Reference :-   Book : Martindale    Page : 636   Edition : 37,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Motion sickness Oral 25 50 mg Tablet/Capsule Taken either the night before or about one hour travelling and repeated every 24 hours if necessary; up to 100 mg daily in divided doses has been given for the treatment of vertigo and vestibular disorders.

Ref :-  Book : Martindale    Page : 634   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Motion sickness 6 Year 12 Year Oral 12.5 mg o.d.
2 Motion sickness 2 Year 6 Year Oral 6.25 mg o.d.

Ref :- Book : Martindale    Page : 634   Edition : 38,
►  Side Effect : CNS depression with effects varying from slight drowsiness to deep sleep and including lassitude, dizziness, and incoordination, Headache, , psychomotor impairment and antimuscarinic effects such as dry mouth, thickened respiratory-tract secretions, blurred vision, urinary difficulty or retention, constipation, and increased gastric reflux.,
Ref :-   Book : Martindale    Page : 635,612   Edition : 38,

►  Drug Interaction : Drug interaction of Meclozine (Meclizine) is with Aminoglycoside antibiotic , Monoamine Oxidase Inhibitor, Tricyclic antidepressant , Antipsychotic , Anxiolytic sedatives, opioid analgesics, Hypnotic , Barbiturates , Alcohol,  Atropine ,
Ref :-   Book : Martindale    Page : 635,614   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Sedating antihistamines may enhance the sedative effects of CNS depressants including alcohol, barbiturates, hypnotics, opioid analgesics, anxiolytic sedatives, and antipsychotics. Sedating antihistamines have an additive antimuscarinic action with other antimuscarinic drugs, such as atropine and some antidepressants (both tricyclics and MAOIs). It has been suggested that some sedating antihistamines could mask the warning signs of damage caused by ototoxic drugs such as aminoglycoside antibiotics. ,
Ref :-   Book : Martindale    Page : 635,614   Edition : 38,


►  Contraindication : alcohol administration, Epilepsy,
Ref :-   Book : Martindale    Page : 635,613   Edition : 38,
  ►  Mechanism of Action :   Inverse agonists that bind preferentially to the inactive conformation of the H1 receptor and shift the equilibrium toward the inactive receptor state. ,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 774   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Onion with Another pathway,

  ►  Pathway with its reference as follows :-
  • antihistamine --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   NA


    ►    Plasma Half-life :
      Min value :-   NA    Max value :-   NA


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA