Mefenamic acid is a Medicine belongs to Non Sterodial Anti- Inflammatory Drugs group whose information about Brand can be referenced from   Book : Martindale    Page : 86   Edition : 38,    Page :   Edition : ,

  ►   Brandname : Ponstel,Dysmen-500,Ponstan; Mefem,Drotin M,Meftal SPas

  ►  Strength : Capsule with 250  mg, Tablet with   ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 656   Edition : 12, Martindale    Page : 86   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral,
Reference :-   Book : Martindale    Page : 86   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Mild to moderate pain Oral 500 mg t.i.d. Not be Given for longer than 7 days at a time.

Ref :-  Book : Martindale    Page : 86   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Still’s disease and fever < 6 Month Oral 25 mg/kg Tablet/Capsule

Ref :- Book : Martindale    Page : 86   Edition : 38,
►  Side Effect : gastrointestinal haemorrhage, ulceration, perforation, nephrotoxicity, Stevens-Johnson syndrome, gastrointestinal disturbance, tinnitus,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 761   Edition : 3,

►  Drug Interaction : Drug interaction of Mefenamic acid is with Bisphosphonates, Alcohol, selective serotonin reuptake inhibitors, Corticosteroid , sulfonylurea antidiabetic , Quinolones, Beta Blockers , Potassium -Sparing Diuretics , Diuretics, Angiotensin converting enzyme inhibitor, Cardiac Glycosides, ,  Misoprostol , Mifepristone , Ritonavir, Zidovudine, Pentoxifylline , Sibutramine, Erlotinib, Iloprost , Ticlopidine , Clopidogrel , Venlafaxine , Phenytoin , Tacrolimus , Cyclosporine , Methotrexate, Phenylbutazone, Azapropazone,
Ref :-   Book : Martindale    Page : 86,107   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Mefenamic acid enhances the effects of oral anticoagulants (especially by azapropazone and phenylbutazone) and increased plasma concentrations of lithium, methotrexate, and cardiac glycosides. The risk of nephrotoxicity may be increased if given with ACE inhibitors, ciclosporin, tacrolimus, or diuretics. There may also be an increased risk of hyperkalaemia with ACE inhibitors and some diuretics, including potassium sparing diuretics. The antihypertensive effects of some antihypertensives including ACE inhibitors, beta blockers, and diuretics may be reduced. Convulsions may occur due to an interaction with quinolones. Mefenamic acid may increase the effects of phenytoin and sulfonylurea antidiabetics. The risk of gastrointestinal bleeding and ulceration associated with Mefenamic acid is increased when used with corticosteroids, the SSRIs, the SNRI venlafaxine, the antiplatelets clopidogrel and ticlopidine, iloprost, erlotinib, sibutramine, or, possibly, alcohol, bisphosphonates, or pentoxifylline. There may be an increased risk of haematotoxicity if zidovudine is used with Mefenamic acid. Ritonavir may increase the plasma concentrations of Mefenamic acid. Licensed product information for mifepristone advises of a theoretical risk that prostaglandin synthetase inhibition by Mefenamic acid or aspirin may alter the efficacy of mifepristone. Mefenamic acid were given with misoprostol although such combinations have sometimes been used to decrease the gastrointestinal toxicity of Mefenamic acid.,
Ref :-   Book : Martindale    Page : 86,107   Edition : 38,


►  Contraindication : gastrointestinal bleeding, intracranial bleeding, Coagulation defect, asthma, urticaria, allergic reactions after taking NSAIDS, severe and fatal anaphylactic reactions, renal insufficiency,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 761   Edition : 3,
  ►  Mechanism of Action :   Inhibit cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2), decreasing the biosynthesis of downstream eicosanoids and thereby limiting the inflammatory response.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 761   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Onion with Another pathway, Fever few with Another pathway,

  ►  Pathway with its reference as follows :-
  • Inhibit prostaglandin formation --- ( PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Postagladil is Inhibit postagladil formation --- (PDR for Herbal medicines. (2000) (4th ed.). U.S. )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- LITHIUM with Most NASDs inhibit the exretion of lithium from the body , resulting in higher blood levels of the mineral , though sulindac .,

      ►  Reference :-
  • Gaby, A. (2006). A–Z Guide to Drug-Herb-Vitamin Interactions. 2nd ed. New York: Three Rivers Press

  •   ►  URL -- http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 86   Edition : 38,


    ►    Plasma Half-life :   Min value :-   2,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 86   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   2 ,    Max value :-   4 hours,
    Ref :-   Book : Martindale    Page : 86   Edition : 38,