Melarsoprol is a Medicine belongs to Antiprotozoals group whose information about Brand can be referenced from   Book : Goodman    Page : 1427   Edition : 12,

  ►   Brandname : MEL B,ARSOBAL

  ►  Strength : Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 934   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion,
Reference :-   Book : Basic & Clinical pharmacology    Page : 933   Edition : 12,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 African trypanosomiasis IV 0.36 1.8 mg/kg Injection Daily in debilitated patients, increased gradually to the maximum daily dose of 3.6 mg/kg. For intermittent cycle therapy, doses are given daily for 3 or 4 days and the course repeated 2 or 3 times with an interval of 7 to 10 days between courses,

Ref :-  Book : Martindale    Page : 934   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 African trypanosomiasis IV 0.36 1.8 mg/kg Injection

Ref :- Book : Martindale    Page : 934   Edition : 38,
►  Side Effect : hypersenstivity, severe febrile reaction, encephalopathy, fever, headache, tremor, slurred speech, convulsion, coma, death, haemorrhagic encephalopathy, vomiting, agranulocytosis, hypertension, peripheral neuropathy, abdominal colic may occur if it is injected too rapidly., severe diarrhoea, proteinuria, myocardial damage, exfoliative dermatitis, Renal and hepatic disturbances,
Ref :-   Book : Martindale    Page : 935   Edition : 38,

►  Drug Interaction : Drug interaction of Melarsoprol is with NA

  ►    Mechanism of Drug Drug Interaction :  ,
Ref :-   Book :    Page :    Edition : ,


►  Contraindication : hypersensitivity to milarsoprol,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 646   Edition : 3,
  ►  Mechanism of Action :   Melarsoprol, a trivalent arsenical derivative, is a trypanocide which appears to act by inhibiting trypanosomal pyruvate kinase.,
Ref :-   Book : Martindale    Page : 934   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- NA


Dietry Substance Interactions


​   ► This Medicine interact with :- NA



ContraIndication Dietry Substance


​   ► This Medicine contraindicate with :- NA

►   Route of Elimination :   Fecal, Renal,
Ref :-   Book : Martindale    Page : 922   Edition : 37,


►    Plasma Half-life :
  Min value :-   It is a prodrug , itself has a plasma half –life 30 minutes.Using biological assay and atomic absorption spectrometry, the terminal half-life was originally calculated to be 35 hr. The half –life of free melarsen oxide (Active form) was 3.9 hr.,    Max value :-   NA
Ref :-   Book : Martindale    Page : 935   Edition : 38,

►    Peak Plasma Concentration :   Min value :-   15 minutes,    Max value :-   NA
Ref :-   Book : Martindale    Page : 935   Edition : 38,