Mercaptopurine is a Medicine belongs to Antineoplastic group whose information about Brand can be referenced from   Book : Martindale    Page : 822   Edition : 38,

  ►   Brandname : Puri-Nethol,Purinethol

  ►  Strength : Tablet with   , Oral Suspension with   , Injection with   ,

Reference of this Medicine for its Strength can be taken from   Book : Martindale    Page : 821   Edition : 38, Martindale    Page : 822   Edition : 38,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : Oral, IV,
Reference :-   Book : Martindale    Page : 821   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Antineoplastic Oral 2.5 mg/kg Tablet Daily.
2 Antineoplastic Oral 50 75 mg/m2 Tablet Daily.

Ref :-  Book : Martindale    Page : 821   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Leukaemia Oral 2.5 mg/kg Tablet
2 Leukaemia Oral 50 75 mg/m2 Tablet

Ref :- Book : Martindale    Page : 821   Edition : 38,
►  Side Effect : bone marrow depression, leucopenia, thrombocytopenia, anaemia, gastrointestinal disturbance, hypoplasia, hepatotoxicity, cholestatic jaundice, necrosis, skin disorders, hyperpigmentation, fever, ,
Ref :-   Book : Martindale    Page : 821   Edition : 38,

►  Drug Interaction : Drug interaction of Mercaptopurine is with Hepatotoxic Drugs,  Allopurinol ,
Ref :-   Book : Martindale    Page : 821   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Mercaptopurine should be given with particular caution with other hepatotoxic drugs. Its effects are enhanced by allopurinol and the dose of mercaptopurine should be reduced to one-third to one-quarter of the usual dose when allopurinol is also given.,
Ref :-   Book : Martindale    Page : 821   Edition : 38,


►  Contraindication : hepatic impairment, renal impairment, Severe bone marrow depression,
Ref :-   Book : Martindale    Page : 821   Edition : 38,
  ►  Mechanism of Action :   Mercaptopurine is an antineoplastic that acts as an antimetabolite. It is an analogue of the natural purines hypoxanthine and adenine. After the intracellular conversion of mercaptopurine to active nucleotides, including thioinosinic acid, it appears to exhibit a variety of actions including interfering with nucleic acid synthesis. It also has immunosuppressant properties. Its actions are specific for cells in S phase.,
Ref :-   Book : Martindale    Page : 821   Edition : 38,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Turmeric with Another pathway, Taurine with same pathway,

  ►  Pathway with its reference as follows :-
  • Curcumin block the transformation, proliferation and invasion of tumor cells, curcumin suppresses the growth of several tumor cell lines, including drug resistant lines. --- (18. PDR for Herbal medicines. (2000) (4th ed.). U.S. )
  • Curcumin block the transformation, proliferation and invasion of tumor cells, curcumin suppresses the grwoth of several tumor cell lines, including drug resistant lines. --- (Weizhang, W. (2010). Anticancer activities of curcumin on human hepatocarcinoma cell line Sk-hep-1. China Journal Of Chinese Matera Medica, 35(4). http://dx.doi.org/10.4268/cjcmm20100417 )

  •   ►  URL -- http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf, http://europepmc.org/abstract/med/20450049,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- KELP with Taking high dose could provide too much iodine and interfere with the action of this medicine., PANTOTHENIC ACID (B5) with Impairs pantothenic acid metabolism. , ZINC with Increases zinc requirement .,

      ►  Reference :-
  • PDR for herbal medicine. (2016) (4th ed.). Thomson Reuters, 2007.
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart
  • Michael, Z. (2007). Hand book of nutrition. New York: Thieme Stuttgart

  •   ►  URL -- ed.). U.S. http://www.travolekar.ru/arch/Pdr_for_Herbal_Medicines.pdf , http://www.lifestyle-clinic.net/wp-content/uploads/2013/07/A-Z_Guide.pdf,

    ►   Route of Elimination :   Renal, Hepatic (Metabolism),
    Ref :-   Book : Martindale    Page : 822   Edition : 38,


    ►    Plasma Half-life :   Min value :-   Plasma half-lives ranging from about 20 to 90 minutes have been reported after intravenous injection and the drug is not found in plasma after about 8 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 822   Edition : 38,


    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA