Meropenem is a Medicine belongs to Antibacterials group whose information about Brand can be referenced from   Book : Martindale    Page : 322   Edition : 38,

  ►   Brandname : Meronem,Merrem; Ameropem; Amropenem; Cosmor

  ►  Strength : Injection with 0.5, 1  g per vial ,

Reference of this Medicine for its Strength can be taken from   Book : Basic & Clinical pharmacology    Page : 808   Edition : 12,
A Route of administration in pharmacology and toxicology is the path by which a drug, fluid, poison, or other substance is taken into the body. Routes of administration are generally classified by the location at which the substance is applied. Common examples include oral and intravenous administration.

  ►  Route of administration : IV infusion,
Reference :-   Book : Martindale    Page : 321   Edition : 38,

Dosing of Medicine differ in Adult & Pediatrics ↓


Adult Dose

S.No Ailment   Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency   Additional Info
1 Susceptible gram-positive and gram negative bacterial infection IV infusion 0.5 1 gm Injection t.i.d. Infusion over 15 to 30 minutes
2 Meningitis IV 2 gm Injection t.i.d.
3 Bronchopulmonary infections in cystic fibrosis IV 2 gm Injection t.i.d.

Ref :-  Book : Martindale    Page : 321   Edition : 38,




Pediatric Dose

S.No Ailment   Age Min   Age Max   Weight ( Kg ) Route   Dose Min   Dose Max   Unit   Dosage Form   Frequency  Additional Info  
1 Severe infection and meningitis under 7 days IV 20 mg/kg Injection b.d.
2 Severe infection and meningitis 7 Day 28 Day IV 20 mg/kg Injection t.i.d.
3 Meningitis and Bronchopulmonary infections in cystic fibrosis. 1 Month 3 Month IV 10 20 mg/kg Injection t.i.d.
4 Susceptible gram-positive and gram negative bacterial infection IV up to 20 mg/kg Injection
5 Susceptible gram-positive and gram negative bacterial infection 3 Month and over IV 10 20 mg/kg Injection t.i.d.
6 Meningitis and Bronchopulmonary infections in cystic fibrosis. 3 Month and over IV 40 mg/kg Injection t.i.d.
7 Susceptible gram-positive and gram negative bacterial infection 3 Month and over over 50 kg IV infusion 0.5 1 gm Injection t.i.d.
8 Meningitis and Bronchopulmonary infections in cystic fibrosis. 3 Months and over over 50 kg IV infusion 2 gm Injection t.i.d.

Ref :- Book : Martindale    Page : 322   Edition : 38, Martindale    Page : 322,321   Edition : 38,
Precaution :- If a Patient is using 'Meropenem' drug in Pyelonephritis disease, then Please be used with dose modifications   if he ever suffered from disease.
Precaution :- If a Patient is using 'Meropenem' drug in Pyelonephritis disease, then Please be used with dose modifications   if he ever suffered from disease.
►  Side Effect : Hypersensitivity reactions such as skin rashes, urticaria, eosinophilia, fever, and, rarely, anaphylaxis, Gastrointestinal effects include nausea, vomiting, diarrhoea, tooth or tongue discoloration, and altered taste, Pseudomembranous colitis, , Local reactions such as pain or thrombophlebitis may occur after injection.,
Ref :-   Book : Martindale    Page : 322,310   Edition : 38,

►  Drug Interaction : Drug interaction of Meropenem is with Probenecid ,
Ref :-   Book : Martindale    Page : 322   Edition : 38,


  ►    Mechanism of Drug Drug Interaction :  Probenecid inhibits the renal excretion of meropenem thereby increasing its plasma concentrations and prolonging its elimination half-life. ,
Ref :-   Book : Martindale    Page : 322   Edition : 38,


►  Contraindication : should be given with caution to patients known to be hypersensitive to penicillins, cephalosporins, or other beta lactams, renal impairment,
Ref :-   Book : Martindale    Page : 322,310   Edition : 38,
  ►  Mechanism of Action :   Beta-lactam inhibit transpeptidase by forming a covalent (“dead-end”) acyl enzyme intermediate.,
Ref :-   Book : Principle of Pharmacology (The Pathophysiologic Basis of Drug Therapy)    Page : 616   Edition : 3,

Pathway of Dietry Product


​   ► Act.Comp / Nutrient / Food / Herb as follows :- Cincona bark with Another pathway,

  ►  Pathway with its reference as follows :-
  • Quinine & Quinidine have Anti-malarial property --- (Kokate, C. (2013). Pharmacognosy (4th ed.). Pune: Nirali Prakashan. )

  •   ►  URL -- http://freepharmadownloads.blogspot.com/2013/02/pharmacognosy-ckkokate-free-download.html,


    Dietry Substance Interactions


    ​   ► This Medicine interact with :- NA



    ContraIndication Dietry Substance


    ​   ► This Medicine contraindicate with :- NA

    ►   Route of Elimination :   Renal,
    Ref :-   Book : Martindale    Page : 322   Edition : 38,


    ►    Plasma Half-life :
      Min value :-   1 hours,    Max value :-   NA
    Ref :-   Book : Martindale    Page : 322   Edition : 38,

    ►    Peak Plasma Concentration :   Min value :-   NA    Max value :-   NA